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dc.contributor.authorVan der Walt, Carel
dc.contributor.authorMalan, Leoné
dc.contributor.authorUys, Aletta S.
dc.contributor.authorMalan, Nicolaas T.
dc.date.accessioned2015-06-03T09:53:23Z
dc.date.available2015-06-03T09:53:23Z
dc.date.issued2013
dc.identifier.citationVan Der Walt, C. et al. 2013. Low grade inflammation and ECG left ventricular hypertrophy in urban African males: the SABPA study. Heart lung and circulation. 22(11):924-929. [http://www.sciencedirect.com/science/journal/14439506]en_US
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/13881
dc.description.abstractBACKGROUND: Hypertension and vascular hyperresponsiveness have been associated with structural wall abnormalities in black Africans. Whether low grade inflammation would have an additive effect is uncertain. Therefore, a novel investigation aimed to assess whether inflammation and pressure overload would have an additive association with ECG left ventricular hypertrophy (LVH). METHODS: We included 75 African and 87 Caucasian males. Ambulatory blood pressure monitoring was done in the working week. A resting 12-lead ECG recording was used for the determination of LVH with the Cornell product formula. Fasting blood samples were obtained for high sensitivity C-reactive protein (hs-CRP) analyses after a controlled overnight stay. Men were stratified into low (≤3 mg/L) and high (>3 mg/L) hs-CRP groups. RESULTS: African men revealed higher ambulatory blood pressure levels compared to Caucasian men independent of hs-CRP levels after adjustment for age, physical activity, cotinine, log γ-GT and body surface area. In forward stepwise linear regression analyses, SBP was positively associated with ECG LVH in all Africans. Considering low grade inflammatory status (>3 mg/L hs-CRP), SBP [Adj R(2)=0.49 (β=0.99, 0.45, 1.44), p≤0.01] and pulse pressure [Adj R(2)=0.61 (β=0.0.34, 0.88), p≤0.01] respectively, predicted ECG LVH in African but not in Caucasian men. CONCLUSIONS: Hyperdynamic blood pressure and inflammation acted in tandem as possible promoting factors to structural wall abnormalities in African men.en_US
dc.description.urihttp://www.sciencedirect.com/science/journal/14439506
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.subjectInflammationen_US
dc.subjectblood pressureen_US
dc.subjectleft ventricular hypertrophyen_US
dc.subjectethnicityen_US
dc.titleLow grade inflammation and ECG left ventricular hypertrophy in urban African males: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID20030223 - Uys, Aletta Sophia
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor


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