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dc.contributor.authorMohammad, Faruq
dc.contributor.authorArfin, Tanvir
dc.identifier.citationMohammed, F. & Arfin, T. 2013. Cytotoxic effects of polystyrene–titanium–arsenate composite in cultured H9c2 cardiomyoblasts. Bulletin of environmental contamination and toxicology. 91:689-696. []en_US
dc.identifier.issn1432-0800 (Online)
dc.description.abstractIn the present report, we explored the toxicological behaviour of engineered polystyrene–titanium– arsenate (PS–Ti–As) composite using cultured H9c2 cardiomyoblasts in vitro. From in vitro cytotoxicity studies, it appears that the composite can be toxic to the cardiac cells and the value of IC50 investigated to be the highest concentration of 500 lg mL-1, during 16–24 h of incubation period. The cell morphological studies based on dual staining with acridine orange and ethidium bromide indicates that apoptosis is the dominating pathway of cell death. Furthermore, an enhanced DNA fragmentation, increased reactive oxygen species production and caspase release demonstrates the potential risks associated with the exposure of PS–Ti–As composite to the cardiac cells.en_US
dc.publisherSpringer Verlagen_US
dc.subjectcationic polymer toxicityen_US
dc.subjectcardiovascular toxicityen_US
dc.subjectDNA fragmentationen_US
dc.subjectROS-induced oxidative stressen_US
dc.subjectcaspase activityen_US
dc.titleCytotoxic effects of polystyrene–titanium–arsenate composite in cultured H9c2 cardiomyoblastsen_US

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