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dc.contributor.authorWolmarans, De Wet
dc.contributor.authorBrand, Linda
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorStein, Dan J.
dc.date.accessioned2015-04-14T08:00:16Z
dc.date.available2015-04-14T08:00:16Z
dc.date.issued2013
dc.identifier.citationWolmarans, D.W. et al. 2013. Reappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) density. Behavioural brain research, 256:545-553. [https://doi.org/10.1016/j.bbr.2013.08.049]en_US
dc.identifier.issn0166-4328
dc.identifier.urihttp://hdl.handle.net/10394/13688
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2013.08.049
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166432813005469
dc.description.abstractObsessive-compulsive disorder (OCD) is characterized by recurrent thoughts and repetitive motor actions. Hyposerotonergic signalling in the cortico-striatal circuitry is believed to be central to the pathology of OCD, while many patients only respond to chronic treatment with high dose selective serotonin (5HT) reuptake inhibitors (SSRIs). Confined deer mice spontaneously develop two forms of stereotypy, namely vertical jumping and pattern running. The purpose of this investigation was to reappraise these behaviours and strengthen the validity of deer mouse stereotypy as an animal model of OCD within a framework of three study questions: (1) can the time spent executing stereotypical behaviours be employed as a measure of extent of stereotypy, (2) does deer mouse stereotypy only respond to chronic, but not sub-chronic treatment with a high-dose SSRI, and (3) is deer mouse stereotypy associated with altered cortico-striatal 5HT transporter (SERT) binding? The current study demonstrates that treatment naïve high stereotypical (HS) deer mice spend significantly more time executing stereotypical behaviours while significantly less time is spent indulging in stereotypy following chronic, but not sub-chronic, treatment with escitalopram. Furthermore, HS deer mice present with a significant decrease in striatal SERT density compared to non-stereotypical (NS) controls. Building on previous validation studies, we conclude that deer mouse stereotypy is a valid naturalistic animal model of OCD with robust face, construct and predictive validity.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectObsessive-compulsive disorder (OCD)en_US
dc.subjectDeer mouseen_US
dc.subjectSerotonin transporter (SERT)en_US
dc.subjectEscitalopramen_US
dc.subjectFrontal cortex-striatumen_US
dc.subjectStereotypyen_US
dc.titleReappraisal of spontaneous stereotypy in the deer mouse as an animal model of obsessive-compulsive disorder (OCD): response to chronic escitalopram treatment and basal serotonin transporter (SERT) densityen_US
dc.typeArticleen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet
dc.contributor.researchID10066357 - Brand, Linda


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