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dc.contributor.authorMouthaan, Joanne
dc.contributor.authorSijbrandij, Marit
dc.contributor.authorDe Vries, Giel-Jan
dc.contributor.authorReitsma, Johannes B.
dc.contributor.authorVan de Schoot, Rens
dc.date.accessioned2015-02-03T12:04:39Z
dc.date.available2015-02-03T12:04:39Z
dc.date.issued2013
dc.identifier.citationMouthaan, J. et al. 2013. Internet-based early intervention to prevent posttraumatic stress disorder in injury patients: randomized controlled trial. Journal of medical internet research , 15(8):1-13. [http://www.jmir.org/]en_US
dc.identifier.issn1439-4456
dc.identifier.issn1438-8871
dc.identifier.urihttp://hdl.handle.net/10394/13286
dc.identifier.urihttp://www.jmir.org/
dc.description.abstractBACKGROUND: Posttraumatic stress disorder (PTSD) develops in 10-20% of injury patients. We developed a novel, self-guided Internet-based intervention (called Trauma TIPS) based on techniques from cognitive behavioral therapy (CBT) to prevent the onset of PTSD symptoms. OBJECTIVE: To determine whether Trauma TIPS is effective in preventing the onset of PTSD symptoms in injury patients. METHODS: Adult, level 1 trauma center patients were randomly assigned to receive the fully automated Trauma TIPS Internet intervention (n=151) or to receive no early intervention (n=149). Trauma TIPS consisted of psychoeducation, in vivo exposure, and stress management techniques. Both groups were free to use care as usual (nonprotocolized talks with hospital staff). PTSD symptom severity was assessed at 1, 3, 6, and 12 months post injury with a clinical interview (Clinician-Administered PTSD Scale) by blinded trained interviewers and self-report instrument (Impact of Event Scale-Revised). Secondary outcomes were acute anxiety and arousal (assessed online), self-reported depressive and anxiety symptoms (Hospital Anxiety and Depression Scale), and mental health care utilization. Intervention usage was documented. RESULTS: The mean number of intervention logins was 1.7, SD 2.5, median 1, interquartile range (IQR) 1-2. Thirty-four patients in the intervention group did not log in (22.5%), 63 (41.7%) logged in once, and 54 (35.8%) logged in multiple times (mean 3.6, SD 3.5, median 3, IQR 2-4). On clinician-assessed and self-reported PTSD symptoms, both the intervention and control group showed a significant decrease over time (P<.001) without significant differences in trend. PTSD at 12 months was diagnosed in 4.7% of controls and 4.4% of intervention group patients. There were no group differences on anxiety or depressive symptoms over time. Post hoc analyses using latent growth mixture modeling showed a significant decrease in PTSD symptoms in a subgroup of patients with severe initial symptoms (n=20) (P<.001). CONCLUSIONS: Our results do not support the efficacy of the Trauma TIPS Internet-based early intervention in the prevention of PTSD symptoms for an unselected population of injury patients. Moreover, uptake was relatively low since one-fifth of individuals did not log in to the intervention. Future research should therefore focus on innovative strategies to increase intervention usage, for example, adding gameplay, embedding it in a blended care context, and targeting high-risk individuals who are more likely to benefit from the intervention. TRIAL REGISTRATION: International Standard Randomized Controlled Trial Number (ISRCTN): 57754429; http://www.controlled-trials.com/ISRCTN57754429 (Archived by WebCite at http://webcitation.org/6FeJtJJyD).en_US
dc.language.isoenen_US
dc.publisherJournal of medical internet researchen_US
dc.subjectEarly interventionen_US
dc.subjectPreventionen_US
dc.subjectInterneten_US
dc.subjectPosttraumatic stress disorderen_US
dc.subjectCognitive behavior therapyen_US
dc.titleInternet-based early intervention to prevent posttraumatic stress disorder in injury patients: randomized controlled trialen_US
dc.typeArticleen_US
dc.contributor.researchID25959565 - Van de Schoot, Adrianus Gerardus Joanes


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