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dc.contributor.authorSemete, Boitumelo
dc.contributor.authorBooysen, Laetitia
dc.contributor.authorKalombo, Lonji
dc.contributor.authorRamalapa, Bathabile
dc.contributor.authorHayeshi, Rose
dc.contributor.authorSwai, Hulda S.
dc.date.accessioned2014-06-27T12:20:33Z
dc.date.available2014-06-27T12:20:33Z
dc.date.issued2012
dc.identifier.citationSemete, B. et al. 2012. Effects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administration. International journal of pharmaceutics, 424(1-2):115-120. [https://doi.org/10.1016/j.ijpharm.2011.12.043]en_US
dc.identifier.issn0967-0874
dc.identifier.issn1366-5863
dc.identifier.urihttp://hdl.handle.net/10394/10764
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517311011732
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2011.12.043
dc.description.abstractThe surface of nanoparticles is often functionalised with polymeric surfactants, in order to increase systemic circulation time. This has been investigated mainly for intravenously administered nanoparticles. This study aims to elucidate the effect of surface coating with various concentrations of polymeric surfactants (PEG and Pluronics F127) on the in vitro protein binding as well as the tissue biodistribution, post oral administration, of PLGA nanoparticles. The in vitro protein binding varied depending on the polymeric surfactant used. However, in vivo, 1% PEG and 1% Pluronics F127 coated particles presented similar biodistribution profiles in various tissues over seven days. Furthermore, the percentage of PEG and Pluronics coated particles detected in plasma was higher than that of uncoated PLGA particles, indicating that systemic circulation time can also be increased with oral formulations. The difference in the in vitro protein binding as a result of the different poloxamers used versus similar in vivo profiles of these particles indicates that in vitro observations for nanoparticles cannot represent or be correlated to the in vivo behaviour of the nanoparticles. Our results therefore suggest that more studies have to be conducted for oral formulations to give a better understanding of the kinetics of the particles.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectNanoparticlesen_US
dc.subjectPEGylationen_US
dc.subjectProtein bindingen_US
dc.subjectBiodistributionen_US
dc.titleEffects of protein binding on the biodistribution of PEGylated PLGA nanoparticles post oral administrationen_US
dc.typeArticleen_US
dc.contributor.researchID12019798 - Booysen, Laetitia Lucretia Ismeralda Josephine


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