Show simple item record

dc.contributor.authorDe Villiers, Melgardt M.
dc.contributor.authorTerblanche, Rudolf J.
dc.contributor.authorLiebenberg, Wilna
dc.contributor.authorSwanepoel, Erna
dc.contributor.authorDekker, Theo G.
dc.date.accessioned2014-05-09T12:26:15Z
dc.date.available2014-05-09T12:26:15Z
dc.date.issued2005
dc.identifier.citationDe Villiers, M.M. et al. 2005. Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole. Journal of pharmaceutical and biomedical analysis, 38(3):435-441. [https://doi.org/10.1016/j.jpba.2005.01.025]en_US
dc.identifier.issn9731-7085
dc.identifier.issn1873-264X
dc.identifier.urihttp://hdl.handle.net/10394/10498
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0731708505000749
dc.identifier.urihttps://doi.org/10.1016/j.jpba.2005.01.025
dc.description.abstractMebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C. Form C is the pharmaceutically preferred form because of its increased aqueous solubility. This paper deals with the use of variable-temperature X-ray powder analysis (VTXRPD) to study the transformation of Form C. Results showed that Form C was stable and transformed to the more stable polymorph A at high temperature (>180 °C). This transformation is a first-order process with activation energy of 238 ± 16 kJ/mole. Further studies showed that compression did not cause any significant changes in the crystal structure of polymorph C.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectMebendazoleen_US
dc.subjectPolymorph transformationen_US
dc.subjectVariable-temperature X-ray powder diffractionen_US
dc.titleVariable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazoleen_US
dc.typeArticleen_US
dc.contributor.researchID10196226 - Liebenberg, Wilna
dc.contributor.researchID10067493 - Swanepoel, Erna
dc.contributor.researchID10173668 - Dekker, Theodor Gerhard


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record