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dc.contributor.authorHindersson, Peter
dc.contributor.authorHuisman, Hugo Willem
dc.contributor.authorKruger, Ruan
dc.contributor.authorOlsen, Michael
dc.contributor.authorSchutte, Aletta Elisabeth
dc.contributor.authorSchutte, Rudolph
dc.date.accessioned2014-02-03T10:30:42Z
dc.date.available2014-02-03T10:30:42Z
dc.date.issued2012
dc.identifier.citationKruger, R. et al. 2012. N-terminal prohormone B-type natriuretic peptide and cardiovascular function in Africans and Caucasians: the SAfrEIC study. Heart lung and circulation, 21(2):88-95. [http://www.heartlungcirc.org/]en_US
dc.identifier.issn1443-9506
dc.identifier.issn1444-2892
dc.identifier.urihttp://hdl.handle.net/10394/10047
dc.identifier.urihttp://dx.doi.org/10.1016/j.hlc.2011.10.009
dc.description.abstractBackground This study compared NT-proBNP levels and the association with cardiovascular markers between Africans and Caucasians from South Africa. Methods This cross-sectional study involved 201 Africans and 255 Caucasians from the North West province, South Africa. Serum NT-proBNP concentrations, blood pressure, pulse wave velocity and arterial compliance were measured. Results NT-proBNP levels were significantly higher (P < 0.001) in Africans than Caucasians, also after adjusting for gender, body mass index (BMI) and pulse wave velocity (P = 0.008). This significant difference became borderline significant after adjusting for systolic blood pressure (SBP) (P = 0.060), and non-significant after adjusting for arterial compliance (P = 0.35). In single regression, a significant positive correlation of NT-proBNP with SBP (r = 0.26; P < 0.001) and pulse pressure (PP) (r = 0.28; P < 0.001) were shown for Africans only. After multiple adjustments, the associations of NT-proBNP with SBP and PP remained significant in Africans (SBP: β = 0.187, P < 0.01; PP: β = 0.234, P < 0.001), with no significant associations in Caucasians. Conclusions NT-proBNP levels were higher in Africans than Caucasians, independently of BMI and gender. This difference was partly driven by higher SBP and lower arterial compliance in Africans. NT-proBNP was persistently associated with SBP and PP in Africans, but not in Caucasians. These associations may suggest early vascular changes contributing to cardiac alterations in Africans.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectNT-proBNPen_US
dc.subjectblood pressureen_US
dc.subjectethnicityen_US
dc.subjectcardiovascular functionen_US
dc.subjectcomplianceen_US
dc.titleN-terminal prohormone B-type natriuretic peptide and cardiovascular function in Africans and Caucasians: the SAfrEIC studyen_US
dc.typeArticleen_US
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID20035632 - Kruger, Ruan
dc.contributor.researchID24239100 - Olsen, Michael Hecht
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph


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