dc.contributor.author | Hindersson, Peter | |
dc.contributor.author | Huisman, Hugo Willem | |
dc.contributor.author | Kruger, Ruan | |
dc.contributor.author | Olsen, Michael | |
dc.contributor.author | Schutte, Aletta Elisabeth | |
dc.contributor.author | Schutte, Rudolph | |
dc.date.accessioned | 2014-02-03T10:30:42Z | |
dc.date.available | 2014-02-03T10:30:42Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Kruger, R. et al. 2012. N-terminal prohormone B-type natriuretic peptide and cardiovascular function in Africans and Caucasians: the SAfrEIC study. Heart lung and circulation, 21(2):88-95. [http://www.heartlungcirc.org/] | en_US |
dc.identifier.issn | 1443-9506 | |
dc.identifier.issn | 1444-2892 | |
dc.identifier.uri | http://hdl.handle.net/10394/10047 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.hlc.2011.10.009 | |
dc.description.abstract | Background
This study compared NT-proBNP levels and the association with cardiovascular markers between Africans and Caucasians from South Africa.
Methods
This cross-sectional study involved 201 Africans and 255 Caucasians from the North West province, South Africa. Serum NT-proBNP concentrations, blood pressure, pulse wave velocity and arterial compliance were measured.
Results
NT-proBNP levels were significantly higher (P < 0.001) in Africans than Caucasians, also after adjusting for gender, body mass index (BMI) and pulse wave velocity (P = 0.008). This significant difference became borderline significant after adjusting for systolic blood pressure (SBP) (P = 0.060), and non-significant after adjusting for arterial compliance (P = 0.35). In single regression, a significant positive correlation of NT-proBNP with SBP (r = 0.26; P < 0.001) and pulse pressure (PP) (r = 0.28; P < 0.001) were shown for Africans only. After multiple adjustments, the associations of NT-proBNP with SBP and PP remained significant in Africans (SBP: β = 0.187, P < 0.01; PP: β = 0.234, P < 0.001), with no significant associations in Caucasians.
Conclusions
NT-proBNP levels were higher in Africans than Caucasians, independently of BMI and gender. This difference was partly driven by higher SBP and lower arterial compliance in Africans. NT-proBNP was persistently associated with SBP and PP in Africans, but not in Caucasians. These associations may suggest early vascular changes contributing to cardiac alterations in Africans. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | NT-proBNP | en_US |
dc.subject | blood pressure | en_US |
dc.subject | ethnicity | en_US |
dc.subject | cardiovascular function | en_US |
dc.subject | compliance | en_US |
dc.title | N-terminal prohormone B-type natriuretic peptide and cardiovascular function in Africans and Caucasians: the SAfrEIC study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10062718 - Huisman, Hugo Willem | |
dc.contributor.researchID | 20035632 - Kruger, Ruan | |
dc.contributor.researchID | 24239100 - Olsen, Michael Hecht | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 12201405 - Schutte, Rudolph | |