Browsing by Subject "metabolomics"
Now showing items 1-10 of 12
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Can metabolomics improve tuberculosis diagnostics?
(Springer, 2014)With one third of the global human population suffering from tuberculosis (TB) in 2001, the disease was officially declared a worldwide emergency by the World Health Organization. Since then this disease has grown ... -
Differentiating between types of meningitis in a paediatric population using ¹H-NMR metabolomics
(North-West University (South Africa), 2020)Meningitis is a disease characterized by the inflammation of the meninges and spinal cord that is most commonly caused by viruses and bacteria and can be classified into two categories. 1) Acute meningitis (rapid onset), ... -
The metabolic profiling of cheetahs (Acinonyx jubatus) : a systems biology approach to understanding the chronic diseases they suffer in captivity
(North-West University, 2017)In captivity, cheetahs (Acinonyx jubatus) are known to frequently suffer from several chronic diseases including lymphoplasmacytic gastritis, glomerulosclerosis, renal amyloidosis, veno-occlusive disease of the liver, ... -
A metabolomics investigation of a hyper- and hypo-virulent phenotype of Beijing lineage M. tuberculosis
(Springer, 2012)Despite a number investigations using rapid sequencing and comparative genomic techniques, attempting to characterise the phenomenon of varying degrees of virulence within the Mycobacterium tuberculosis species, the ... -
A metabolomics investigation of a nanogold drug vehicle on experimental animals
(North-West University (South Africa), 2019-05)Nanotechnology has increasingly received attention the last few decades and the term refers to the categories of applied science and technology, where the combining key subject is the study of matter in scales of 1 to 100 ... -
A metabolomics investigation of Fibromyalgia Syndrome
(North-West University, 2018)This thesis, entitled: "A metabolomics investigation of Fibromyalgia Syndrome", deals with Fibromyalgia Syndrome (FMS), a chronic widespread pain disorder with an estimated prevalence of 3.2% in the South African general ... -
A metabolomics investigation on experimental interventions of acute alcohol consumption
(North-West University, 2018)This thesis, titled: "A metabolomics investigation on experimental interventions of acute alcohol consumption", deals with a current topic of global interest, namely, alcohol use and abuse. Alcohol abuse is associated with ... -
A putative urinary biosignature for diagnosis and follow-up of tuberculous meningitis in children: outcome of a metabolomics study disclosing host-pathogen responses
(Springer, 2016)Introduction: Tuberculous meningitis (TBM) is a severe manifestation of tuberculosis, presenting with high morbidity and mortality in children. Existing diagnostic methods for TBM are invasive and time-consuming and the ... -
Qualitative serum organic acid profiles of HIV-infected individuals not on antiretroviral treatment
(Springer, 2012)The first application of gas chromatography mass spectrometry (GC–MS) metabolomics to the analysis of organic acid profiles in sera of asymptomatic human immunodeficiency virus (HIV)-infected individuals (n = 18) ... -
Untargeted metabolite profiling of abalone using gas chromatography mass spectrometry
(Springer, 2016)Abalone meat is a delicacy worldwide, fetching high prices and a valuable source of income for the many countries farming and exporting this commodity. The quality of abalone is based on its unique sensory properties and ...