Browsing by Subject "Zebrafish"
Now showing items 1-9 of 9
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Abnormal repetitive behaviors in zebrafish and their relevance to human brain disorders
(Elsevier, 2019)Abnormal repetitive behaviors (ARBs) are a prominent symptom of numerous human brain disorders and are commonly seen in rodent models as well. While rodent studies of ARBs continue to dominate the field, mounting evidence ... -
Cross-species analyses of intra-species behavioral differences in mammals and fish
(Elsevier, 2020)Multiple species display robust behavioral variance among individuals due to different genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various ... -
Development and validation of a post-traumatic stress disorder model in zebrafish
(North-West University (South-Africa), 2021)Post-traumatic stress disorder (PTSD) is a severely debilitating chronic mental disorder brought about by encountering an actual or perceived, life-threatening or traumatic experience or series of events, like violence or ... -
Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)
(North-West University (South-Africa), 2020)Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ... -
Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action
(Elsevier, 2020)Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test ... -
How toxic is a non-toxic nanomaterial: behaviour as an indicator of effect in Danio rerio exposed to nanogold
(Elsevier, 2019)Gold nanoparticles are used as drug delivery vectors based on the assumption that they have low toxicity. Literature has, however, produced conflicting results over the last few years. As such, this study aimed to investigate ... -
Investigating the effect of anaesthesia on the metabolism of zebrafish (D. rerio)
(North-West University (South Africa), 2022)In recent years, zebrafish (D. rerio) have emerged as valuable research models, being widely used as models for aquaculture research, but also to model human metabolic diseases. The ethical guidelines stipulate that ... -
Life-threatening, high-intensity trauma- and context-dependent anxiety in zebrafish and its modulation by epinephrine
(Elsevier, 2023)Trauma-related psychopathology transpires in some individuals after exposure to a life-threatening event. While aberrant adrenergic processes may contribute to this, a clear understanding of how said processes influence ... -
A pharmacological investigation of behavioural flexibility in zebrafish (Danio rerio)
(North-West University (South-Africa), 2022)Human and animal behaviour is ultimately directed at acquiring certain outcomes or achieving certain goals, or alternatively avoiding or mitigating negative outcomes. An intricate interplay between two components of ...
