Browsing by Subject "Tetralone"

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Anti-trypanosomal and antimalarial properties of tetralone derivatives and structurally related benzocycloalkanones

Beteck, Richard M.; Legoabe, Lesetja J.; Isaacs, Michelle; Khanye, Setshaba D.; Laming, Dustin (MDPI, 2019)

Background and objectives: Sleeping sickness and malaria alike are insect-borne protozoan diseases that share overlapping endemic areas in sub-Saharan Africa. The causative agent for malaria has developed resistance ...
Synthesis and evaluation of 2-benzylidene-1-tetralone derivatives for monoamine oxidase inhibitory activity

Amakali, Klaudia T.; Legoabe, Lesetja J.; Petzer, Anél; Petzer, Jacobus P. (Bentham Science, 2018)

Background: Chalcone has been identified as a promising lead for the design of Monoamine Oxidase (MAO) inhibitors. This study attempted to discover potent and selective chalcone-derived MAO inhibitors by synthesising a ...