Browsing by Subject "Schizophrenia"
Now showing items 1-10 of 23
-
Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ... -
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Clozapine usage in a public sector psychiatric hospital in the Nelson Mandela Metropole
(2013)About 30.00% of schizophrenic patients fail to respond to conventional antipsychotics. Clozapine shows superior efficacy, for both the positive and negative symptoms of schizophrenia, over conventional antipsychotics. The ... -
A consideration of the potential taxation of Cannabis in South Africa
(North-West University (South Africa), 2020)Taxation is part of the daily lives of most persons in the world. A new product supplied into a market is likely to be subject to some form of taxation. Taxation of a new product for example cannabis requires rigorous ... -
The effects of sub-chronic clozapine and haloperidol administration on isolation rearing induced changes in frontal cortical n-methyl-d-aspartate and d1 receptor binding in rats
(Elsevier, 2010)Glutamate and dopamine disturbances are implicated in frontal cortical dysfunction in schizophrenia. Little, however, is known about the nature of dopamine D1 and N-methyl-d-aspartate (NMDA) receptor interactions in the ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
(Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Evaluation of selected dye compounds as inhibitors of enzymes, relevant to neurological disorders
(North-West University (South-Africa), 2021)Neurological disorders such as Alzheimer’s disease, Parkinson’s disease and schizophrenia are disorders that affect a large part of the population, especially the elderly. The cause of these disorders is still not completely ... -
Factors associated with prescribing and dispensing of schizophrenia treatment in the private health sector of South Africa
(North-West University (South Africa) , Potchefstroom Campus, 2015)The aim of this study was to determine the prevalence, medicine prescribing patterns and maximum potential savings through generic substitution in direct treatment costs associated with schizophrenia in the private health ...
