Browsing by Subject "Oxidative stress"
Now showing items 1-10 of 55
-
A 3-methylcrotonyl-CoA carboxylase deficient human skin fibroblast transcriptome reveals underlying mitochondrial dysfunction and oxidative stress
(Elsevier, 2016)Isolated 3-methylcrotonyl-CoA carboxylase (MCC) deficiency is an autosomal recessive inherited metabolic disease of leucine catabolism with a highly variable phenotype. Apart from extensive mutation analyses of the MCCC1 ... -
Agrochemicals related to maize crops in South Africa and associated biological effects : an in vitro study
(North-West University (South Africa), 2023)Although agrochemicals reduce pest-associated crop losses, these chemicals end up in non-target environments following rainfall and irrigation. When fractions of agrochemical mixtures are bioavailable, they pose a threat ... -
Anticancer activities of oxidant-redox drug combinations in lipid excipients
(North-West University, 2018)Genetic alterations in the redox status of cancer cells promotes a continuous and elevated production of reactive oxygen species (ROS), associated in the initiation and progression of tumours. The body's potent antioxidant ... -
Antioxidant enzyme activity is associated with blood pressure and carotid intima media thickness in black men and women: the SABPA study
(Elsevier, 2016)In the urbanized black population of South Africa, oxidative stress may play a crucial role in the development of hypertension. Since oxidative stress may result from impaired antioxidant capacity we aimed to investigate ... -
Appraisal of ozone as biologically active molecule and experimental tool in biomedical sciences
(Springer, 2011)Ozone (O3) (CAS 10028-15-6) is a major air industrial pollutant and is well known for its very strong oxidative actions which affords the molecule its useful antimicrobial and deodorizing properties, but also its potential ... -
Artemisone and artemiside are potent panreactive antimalarial agents that also synergize redox imbalance in Plasmodium falciparum transmissible gametocyte stages
(American Society for Microbiology, 2018)The emergence of resistance toward artemisinin combination therapies (ACTs) by the malaria parasite Plasmodium falciparum has the potential to severely compromise malaria control. Therefore, the development of new artemisinins ... -
Association analysis of genetic variants related to biotransformation, estrogen metabolism, and oxidative stress
(North-West University (South Africa), 2023)In a previous study by the NWU eBOSS research group, urinary oestrogen biotransformation metabolite levels and blood oxidative stress markers were measured in African and Caucasian premenopausal South African women. ... -
The association of endothelin-1 with markers of oxidative stress in a biethnic South African cohort: the SABPA study
(Springer Nature, 2017)Both endothelin-1 and oxidative stress have important roles in the development of cardiovascular diseases such as hypertension and atherosclerosis. Limited information is available on the interaction between oxidative ... -
Associations between reactive oxygen species, blood pressure and arterial stiffness in black South Africans: the SABPA study
(Springer Nature, 2012)Many mechanisms, including oxidative stress, contribute to hypertension. This study investigated the possible associations between oxidative stress, blood pressure and arterial stiffness in black South Africans. Ambulatory ... -
Baseline bio-accumulation concentrations and resulting oxidative stress in Synodontis zambezensis after an acute laboratory exposure to 4,4′-DDT
(Elsevier, 2019)The use of 1,1′-(2,2,2-Trichloro-1,1-ethanediyl)bis(4-chlorobenzene) (DDT) as a pesticide for the control of insects vectors responsible for the spread of many life threatening diseases was officially banned in 1972 by the ...
