Browsing by Subject "OXPHOS deficiency"

Now showing items 1-2 of 2

An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies

Reinecke, Fimmie (North-West University, 2010)

Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ...
Mitochondrial DNA replication and OXPHOS gene transcription show varied responsiveness to Rieske protein knockdown in 143B cells

Levanets, Oksana; Reinecke, Fimmie; Louw, Roan; Pretorius, Pieter J.; Du Plessis, Lissinda H.; Van der Westhuizen, Francois H. (Elsevier, 2011)

Genetic, biochemical and phenotypic diversity is a hallmark of OXPHOS deficiencies. Among the responses frequently reported for these deficiencies is differential expression of several genes involved in mitochondrial ...