Browsing by Subject "Muscarinic acetylcholine receptor"

Now showing items 1-3 of 3

Antagonism by selected classical irreversible competitive antagonists : an investigation into the proposed non-specific mechanisms involved

Bodenstein, Johannes (North-West University, 2003)

Many irreversible antagonists are known to bind irreversibly to pharmacological receptors. However, few studies suggest that these irreversible antagonists may also display irreversible non-specific antagonism by binding ...
Appearance of antidepressant-like effect by sildenafil in rats after central muscarinic receptor blockade: evidence from behavioural and neuro-receptor studies

Brink, C.B.; Clapton, J.D.; Eagar, B.E.; Harvey, Brian Herbert (Springer, 2008)

The phosphodiesterase (PDE) 5 inhibitor sildenafil has been shown to display psychotropic actions in humans and animals, and has been used for the treatment of antidepressant-associated erectile dysfunction. However, its ...
The modulating effect of sildenafil on cell viability and on the function of selected pharmacological receptors in cell cultures

Eager, Blenerhassit Edward (North-West University, 2004)

Since sildenafil's (Viagra®), a phospodiesterase type 5 (PDE5) inhibitor, approval for the treatment of male erectile dysfunction (MED) in the United States early 1998, 274 adverse event reports were filed by the Food and ...