Browsing by Subject "Monoamine oxidase inhibitors"
Now showing items 1-9 of 9
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Antidepressant effects of coumarins and their derivatives: A critical analysis of research advances
(Elsevier, 2023)Coumarins and their derivatives are non-flavonoids polyphenols with diverse pharmacological activities including anti-depressant effects. This study systematically examines the antidepressant effects of coumarins and ... -
Monoamine oxidase inhibitory activities of heterocyclic chalcones
(2013)Parkinson’s disease is the second most common age-related neurodegenerative disease after Alzheimer’s disease. The characteristic pathological feature of Parkinson’s disease is the loss of neurons in the substantia nigra ... -
Neuroprotective effects of amantadine–flavonoid conjugates
(North-West University, 2011)Neurodegenerative disorders like Parkinson’s and Alzheimer’s disease affect millions of people around the world. Oxidative stress has been implicated in the pathogenesis of a number of neurodegenerative disorders, cancer ... -
Novel monoamine oxidase inhibitors: a patent review (2012-2014)
(Taylor & Francis, 2015)Introduction: Monoamine oxidase (MAO) inhibitors, despite the initial pharmacological interest, are used in clinic for their antidepressant effect and in the management of Parkinson symptoms, due to the established ... -
Novel sulfanyl– and sulfinylcaffeine analogues as inhibitors of monoamine oxidase
(North-West University, 2013)Parkinson’s disease (PD) is a neurodegenerative disorder, which is progressive in nature and usually associated with the elderly. It is the second most common age-related neurodegenerative disorder after Alzheimer’s disease ... -
Syntheses of chalcones and 2–aminopyrimidines and their evaluation as monoamine oxidase inhibitors and as adenosine receptor antagonists
(North-West University, 2013)Background and rationale - Parkinson’s disease is a neurodegenerative disorder characterised by reduced levels of dopamine in the brain. The cause of Parkinson's disease is still unknown; however several theories pertaining ... -
Synthesis and evaluation of chromone derivatives as inhibitors of monoamine oxidase
(2014)BACKGROUND AND RATIONALE Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder affecting the central nervous system, primarily, the substantia nigra. It is characterized by loss of dopaminergic ... -
Synthesis and evaluation of cyclic chalcones as monoamine oxidase inhibitors
(North-West University (South Africa) , Potchefstroom Campus, 2016)Parkinson’s disease (PD) is the second most-prevalent age-related neurodegenerative disorder following Alzheimer’s disease. The manifestation of clinical PD begins after a loss of neurons from the substantia nigra pars ... -
The synthesis and evaluation of tetralone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamienoksidase (MAO)-inhibeerders word gebruik vir die behandeling van toestande wat veroorsaak word deur verlaagde vlakke van neuro-oordragstowwe soos dopamien, noradrenalien en serotonien. MAO-inhibeerders is aanvanklik ...
