Browsing by Subject "Mitochondrial-nuclear communication"
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An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies
(North-West University, 2010)Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ...