Browsing by Subject "Mitochondrial DNA"
Now showing items 1-10 of 11
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The aetiology of cardiovascular disease: a role for mitochondrial DNA?
(Clinics Cardive Publishing, 2018)Cardiovascular disease (CVD) is a world-wide cause of mortality in humans and its incidence is on the rise in Africa. In this review, we discuss the putative role of mitochondrial dysfunction in the aetiology of CVD and ... -
Characterization of mtDNA variation in a cohort of South African paediatric patients with mitochondrial disease
(Springer Nature, 2012)Mitochondrial disease can be attributed to both mitochondrial and nuclear gene mutations. It has a heterogeneous clinical and biochemical profile, which is compounded by the diversity of the genetic background. Disease-based ... -
Could we offer mitochondrial donation or similar assisted reproductive technology to South African patients with mitochondrial DNA disease?
(HMPG, 2016)The decision of the UK House of Commons in 2015 to endorse the use of pioneering in vitro fertilisation techniques to protect future generations from the risk of mitochondrial DNA (mtDNA) disease has sparked worldwide ... -
High parasite diversity in a neglected host: larval trematodes of Bithynia tentaculata in Central Europe
(Cambridge Univ Press, 2020)Bithynids snails are a widespread group of molluscs in European freshwater systems. However, not much information is available on trematode communities from molluscs of this family. Here, we investigate the trematode ... -
Implementing a new variant load model to investigate the role of mtDNA in oxidative stress and inflammation in a bi-ethnic cohort: the SABPA study
(Taylor & Francis, 2019)Mitochondrial DNA (mtDNA) variation has been implicated in several common complex and degenerative diseases, including cardiovascular disease. Inflammation is seen as part of many of these conditions. Mitochondria feature ... -
Investigating gene mutations in a South African paediatric cohort diagnosed with mitochondrial disease
(North-West University (South Africa). Potchefstroom Campus, 2019)Mitochondrial diseases (MD) are a clinically heterogenous group of genetic disorders that affect the neuromuscular system, the central nervous system (collectively known as encephalomyopathies), and other high-energy ... -
Investigation of the involvement of mitochondrial DNA variants in cardiometabolic disease : the SABPA study
(North-West University (South Africa), Potchefstroom Campus, 2017)Mitochondria are intricately involved in cell homeostatic and adaptive stress signalling pathways, and play a central role in cell differentiation, proliferation and death. Consequently, mitochondrial dysfunction has been ... -
The mitochondrial DNA heritage of the Baganda, Lugbara and Acholi from Uganda
(North-West University, 2010)The mtDNA genetic relatedness between and within 13 Baganda, 14 Lugbara and 13 Acholi individuals from Uganda was investigated in this research program. The complete mtDNA sequences of the 40 Ugandan samples were established ... -
The role of mitochondria in ME/CFS: a perspective
(Taylor & Francis, 2019)Chronic fatigue syndrome (CFS) also known as Myalgic encephalomyelitis (ME) is a debilitating disease, characterized by the symptom of severe fatigue. ME/CFS is a heterogeneous condition in both clinical presentation and ... -
The unresolved role of mitochondrial DNA in Parkinson's disease: an overview of published studies, their limitations, and future prospects
(Elsevier, 2019)Parkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining ...
