Browsing by Subject "Methylene blue"
Now showing items 1-10 of 18
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The antidepressant properties of selected methylene blue analogues
(2014)The shortcomings of current antidepressant agents prompts the design of novel multimodal antidepressants and the identification of new antidepressant targets, especially those located at sub-cellular level. Such ... -
Azure B and a synthetic structural analogue of methylene blue, ethylthioninium chloride, present with antidepressant-like properties
(Elsevier, 2014)Aims: The phenothiazinium compound, methylene blue (MB), possesses diverse pharmacological actions and is attracting attention for the treatment of bipolar disorder and Alzheimer's disease. MB acts on both monoamine oxidase ... -
Azure B, a metabolite of methylene blue, is a high-potency, reversible inhibitor of monoamine oxidase
(Elsevier, 2012)Methylene blue (MB) has been shown to act at multiple cellular and molecular targets and as a result possesses diverse medical applications. Among these is a high potency reversible inhibition of monoamine oxidase A ... -
Biosynthesis and photocatalytic properties of SnO2 nanoparticles prepared using aqueous extract of cauliflower
(Springer, 2017)This work reports the biosynthesis of Sn(OH)2 using aqueous extract of fresh cauliflower (Brassica oleracea L. var. botrytis), and the subsequent preparation of SnO2 nanoparticles at two different annealing temperatures ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University (South Africa), Potchefstroom Campus, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
Evaluation of selected dye compounds as inhibitors of enzymes, relevant to neurological disorders
(North-West University (South-Africa), 2021)Neurological disorders such as Alzheimer’s disease, Parkinson’s disease and schizophrenia are disorders that affect a large part of the population, especially the elderly. The cause of these disorders is still not completely ... -
Evaluation of selected dye compounds as inhibitors of monoamine oxidase
(North-West University (South-Africa), 2019)Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative diseases that significantly impact the quality of life of patients. The pathology of Parkinson’s disease is characterised by neuronal death of the ... -
The interactions of azure B, a metabolite of methylene blue, with 2 acetylcholinesterase and butyrylcholinesterase
(Elsevier, 2014)Methylene blue(MB) is reported to possess diverse pharmacological actions and is attracting increasing attention for the treatment of neurodegenerative disorders such as Alzheimer's disease. Among the pharmacological actions ... -
Methylene blue analogues : in vitro antimicrobial activity and in silico pharmacophore modelling
(North-West University (South-Africa), 2021)Antibiotics have drastically reduced the morbidity and mortality associated with fatal infections and have made previously impossible procedures, e.g. heart surgery, possible by allowing infections to be prevented or ...
