Browsing by Subject "Metallothioneins"
Now showing items 1-5 of 5
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Bioaccumulation and metal-associated biomarker responses in a freshwater mussel, Dreissena polymorpha, following short-term platinum exposure
(Elsevier, 2019)Due to the increasing presence of platinum (Pt) in the environment, the caveat arises to identify its toxic potential in species at risk of being exposed – especially those found in aquatic environments where pollutants ... -
The Effect of Metallothionein Overexpression on Inflammation Associated with Mitochondrial Complex I Deficiency
(North-West University (South Africa)North-West University, 2020)Mitochondria form an integral part of the immune system because complex I (CI) of the mitochondrial oxidative phosphorylation system has been identified as a key regulator of the inflammatory response. CI activity suppresses ... -
An evaluation of mitochondrial DNA replication and transcription as well as the transcription of selected nuclear genes in in vitro models for OXPHOS deficiencies
(North-West University, 2010)Deficiencies of the oxidative phosphorylation system (OXPHOS) that consists of five enzyme complexes (I-IV) lead to a diversity of cellular consequences. This includes altered Ca2+ homeostasis, reduced ATP production and ... -
Metallothionein involvement in mitochondrial function and disease : a metabolomics investigation
(North-West University, 2011)One of the many recorded adaptive responses in respiratory chain complex I deficient cells is the over-expression of the small metal binding proteins, metallothioneins (MTs). The antioxidant properties of MTs putatively ... -
The use of Clarias gariepinus and associated helminthic parasites as bio-indicators of metal pollution in a subtropical ecosystem
(North-West University (South Africa), 2020)Metals are naturally occurring elements that play an important role in the functioning of organisms. However, imbalances in metal concentrations in the environment are of great concern due to their potential detrimental ...