Browsing by Subject "Major depressive disorder"
Now showing items 1-8 of 8
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An analysis of antidepressant noncompliance in the private health sector of South Africa
(2014)The main aim of the thesis was to measure antidepressant (AD) non-compliance, to determine which factors are closely associated with AD non-compliance and the consequences of prolonged AD non-compliance in the private ... -
Animal models of major depressive disorder and the implications for drug discovery and development
(Taylor & Francis, 2019)Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is ... -
Comparative study of N-acetyl cysteine and an experimental xanthone compound on behavioral, immune-inflammatory and redox biomarkers of depression in the Flinders sensitive line rat
(North-West University (South-Africa). Potchefstroom Campus, 2016)The focus of determining the underlying pathophysiological pathways of major depressive disorder (MDD) has shifted from identifying one single hypothesis to the incorporation of various aspects of the disease. Increasing ... -
Cyberbullying and its effects on the mental well-being of adolescents
(North-West University (South Africa)., 2020)Studies investigating the effects of cyberbullying on the mental well-being of adolescents are needed to guide the development of preventive and protective measures for cyberbullying. Although a substantial number of studies ... -
The impact of HIV/AIDS on compliance with antidepressant treatment in major depressive disorder: a prospective study in a South African private healthcare cohort
(BioMed Central, 2015)Background: MDD and HIV/AIDS have a high prevalence worldwide with severe consequences for patients. In both conditions, compliance with treatment is key to successfully treat these disorders. In the current study, ... -
Long-lasting bio-behavioural effects of early-life sildenafil administration in stress-sensitive versus healthy control rats
(North-West University (South-Africa). Potchefstroom Campus, 2019)Major depressive disorder (MDD) in children and adolescents is prevalent, serious and of great concern globally. Yet, only two selective serotonin reuptake inhibitors (SSRIs) are approved for the treatment of juvenile MDD, ... -
Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats
(Elsevier, 2017)Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that ... -
Prospective analysis of the medicine possession ratio of antidepressants in the private health sector of South Africa, 2006-2011
(Health & Medical Publishing Group, 2015)Background: Major depressive disorder (MDD) is a disabling mental illness with high morbidity and mortality rates. Inadequate treatment efficacy, unfavourable side-effect profiles and consequent shortfalls in compliance ...
