Browsing by Subject "LDL-C"

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C679X loss-of-function PCSK9 variant lowers fasting glucose levels in a black South African population: a longitudinal study

Chikowore, Tinashe; Cockeran, Marike; Conradie, Karin R.; Van Zyl, Tertia (Elsevier, 2018)

Aims To determine the longitudinal association of the loss-of-function (LOF) PCSK9 variants (C679X and A443T), proxies of PCSK9 inhibitor drugs, with LDL-C, fasting glucose and glycated hemoglobin. Methods We conducted ...
Common and rare single nucleotide polymorphisms in the LDLR gene are present in a black South African population and associate with low-density lipoprotein cholesterol levels

Van Zyl, Tertia; Jerling, Johann C.; Conradie, Karin R.; Feskens, Edith J.M. (Nature Publishing Group, 2014)

The LDL receptor has an essential role in regulating plasma LDL-C levels. Genetic variation in the LDLR gene can be associated with either lower or moderately raised plasma levels of LDL-C, or may cause familial ...