Browsing by Subject "Innate immune response"
Now showing items 1-3 of 3
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Investigating the importance of co-expressed rotavirus proteins in the development of a selection-free rotavirus reverse genetics system
(2014)Reverse genetics is an innovative molecular biology tool that enables the manipulation of viral genomes at the cDNA level in order to generate particular mutants or artificial viruses. The reverse genetics system for the ... -
Preparatory investigations for developing a transcript–based rotavirus reverse genetics system
(North-West University, 2012)Reverse genetics systems that are based on either viral transcripts or cDNA genome segments cloned in plasmids have recently been reported for some of the dsRNA viruses of the Reoviridae family, namely African horsesickness ... -
Rational design of rotavirus NSP1 and NSP4 to improve the safety profile of rotavirus vaccine candidates
(North-West University (South Africa), 2023-12)Rotaviruses cause acute gastroenteritis and are the leading cause of diarrhoea-related hospitalisations and deaths worldwide in children under the age of 5. Currently available live-attenuated rotavirus vaccines have ...
