Browsing by Subject "Inflexibility"

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Dopaminergic and serotonergic modulation of reward appraisal in the zebrafish (Danio rerio)

Van Staden, Cailin (North-West University (South-Africa), 2020)

Obsessive-compulsive disorder (OCD)1 is a chronic and debilitating neuropsychiatric condition affecting 1 – 3% of the world population. The condition is characterized by two main symptom cohorts namely recurrent, distressing ...
Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action

Van Staden, C.; De Brouwer, G.; Botha, T.L.; Brand, S.J.; Wolmarans, D. (Elsevier, 2020)

Cognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test ...