Browsing by Subject "In vitro model"
Now showing items 1-5 of 5
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Artificial membranes soaked with natural oils for in vitro drug premeability evaluations
(North-West University (South-Africa), 2019)Abstract not copied -
Comparison of drug permeability in rat, pig and human in vitro models
(2015)A crucial step in the drug discovery and development process is the assessment of membrane permeability properties of new chemical entities and researchers are constantly searching for cost-effective, high through-put ... -
Effect of the transport medium composition on in vitro drug permeation across excised pig intestinal tissue
(North-West University (South Africa) , Potchefstroom Campus, 2016)A crucial step in the process of drug research and development is the investigation of permeation characteristics of new chemical entities across biological membranes to give an indication of their pharmacokinetic properties. ... -
Effects of selected pharmaceutical excipients on drug permeation at different gastro-intestinal tract regions
(North-West University (South Africa) , Potchefstroom Campus, 2016)Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as ... -
In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration
(Taylor & Francis, 2016)Introduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques ...