Browsing by Subject "Imidazo[1,2-α]pyridine analogues"

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Imidazo[1,2-α]pyridines possess adenosine A1 receptor affinity for the potential treatment of cognition in neurological disorders

Lefin, Roslyn; Van der Walt, Mietha M.; Milne, Pieter J.; Terre'Blanche, Gisella (Elsevier, 2017)

Previous research has shown that bicyclic 6:5-fused heteroaromatic compounds with two N-atoms have variable degrees of adenosine A1 receptor antagonistic activity. Prompted by this imidazo[1,2-α]pyridine analogues were ...
The synthesis and evaluation of imidazopyridines as adenosine receptor antagonists

Lefin, Roslyn (North-West University (South Africa) , Potchefstroom Campus, 2017)

Alzheimer’s disease (AD) is the most common occurring neurodegenerative disorder worldwide and includes deficiencies in memory and cognitive impairment. Both the hippocampus and cortex are important neuronal areas in the ...