Browsing by Subject "Glycine N-acyltransferase"
Now showing items 1-8 of 8
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Characterization of the enzyme activity and substrate specificity of GLYAT haplotypes
(North-West University (South Africa), 2020)The unavoidable exposure to xenobiotics makes detoxification a necessity. Detoxification is not just one reaction but four reactions (Phase 0, I, II and III) that work together. The glycine conjugation pathway is one of ... -
Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation
(Taylor & Francis, 2013)Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ... -
Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ... -
Investigation of the bi-substrate kinetics of a recombinant human glycine N-acyltransferase with a known non-synonymous single nucleotide polymorphism (N156S)
(North-West University (South Africa), Potchefstroom Campus, 2015)Biotransformation is fast becoming a buzzword of our time. This is due to the ever increasing exposure of humans to xenobiotic substances. The detoxification of these xenobiotics occur via various detoxifying mechanisms ... -
New insights into the catalytic mechanism of human glycine N-acyltransferase
(Wiley, 2017)Even though the glycine conjugation pathway was one of the first metabolic pathways to be discovered, this pathway remains very poorly characterized. The bi-substrate kinetic parameters of a recombinant human glycine ... -
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids
(Taylor & Francis, 2014)A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ... -
A new perspective on the importance of glycine N–acyltransferase in the detoxification of benzoic acid
(2014)Despite being the first biochemical reaction to be discovered, the glycine conjugation pathway remains poorly characterised. It has generally been assumed that glycine conjugation serves to increase the water solubility ... -
The use of p-aminobenzoic acid as a probe substance for the targeted profiling of glycine conjugation
(Wiley, 2016)Glycine conjugation facilitates the metabolism of toxic aromatic acids, capable of disrupting mitochondrial integrity. Owing to the high exposure to toxic substrates, characterization of individual glycine conjugation ...
