Browsing by Subject "Efflux"
Now showing items 1-6 of 6
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Absorptive and secretory transport of selected artemisinin derivatives across Caco-2 cell monolayers
(Bentham Science, 2018)Background: Malaria continues to be a major health concern and affects more than 200 million people a year. Drugs currently used for treatment of malaria are increasingly rendered ineffectual by the ongoing emergence of ... -
Herb-drug pharmacokinetic interactions: transport and metabolism of indinavir in the presence of selected herbal products
(MDPI, 2015)Patients receiving anti-retroviral drug treatment are sometimes simultaneously taking herbal remedies, which may result in pharmacokinetic herb-drug interactions. This study aimed to determine if pharmacokinetic interactions ... -
Impact of selected herbal products on intestinal epithelial permeation and metabolism of indinavir
(2014)Patients on anti-retroviral (ARV) drug treatment are sometimes simultaneously taking other prescribed drugs and/or over-the-counter drugs and/or herbal remedies. Pharmacokinetic drug-drug or herb-drug interactions can occur ... -
Impact of traditional African medicine on drug metabolism and transport
(Taylor & Francis, 2014)Introduction: Africa is a continent of rich plant biodiversity with many indigenous plants having a long history of being used for medicinal purposes. A considerable number of patients consult traditional healers in ... -
Investigation of the pharmacokinetic interactions between Hypoxis hemerocallidea and indinavir
(North-West University (South Africa) , Potchefstroom Campus, 2016)It has been established that phytochemicals in herbal medicines can result in pharmacokinetic interactions when co-administrated with allopathic drugs. These herb-drug pharmacokinetic interactions may lead to an increase ... -
Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue
(Medknow, 2013)Background: Clinically, significant herb-drug interactions have been previously documented and can be pharmacodynamic and/or pharmacokinetic in nature. Pharmacokinetic interactions have been attributed to induction or ...
