Browsing by Subject "ESX-1"

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A metabolomics approach investigating the functionality of the ESX-1 gene cluster in mycobacteria

Swanepoel, Conrad Cilliers (North-West University, 2015)

Tuberculosis (TB) claims the lives of millions of individuals each year, and is consequently the world’s second-most deadly infectious disease after acquired immune deficiency syndrome (AIDS), responsible for 1.4 million ...
A metabolomics investigation of the function of the ESX-1 gene cluster in mycobacteria

Loots, Du Toit; Swanepoel, Conrad C.; Newton-Foot, Mae; Gey van Pittius, Nicolaas C. (Elsevier, 2016)

The ESX-1 gene cluster, encoding the Type-VII secretion (T7S) system and its virulence associated proteins, ESAT-6 and CFP-10, is thought to be responsible for the transport of extracellular proteins across the hydrophobic ...