Browsing by Subject "Drug resistance"
Now showing items 1-8 of 8
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Comparative evaluation of molecular-based detection methods for drug resistant tuberculosis
(North-West University (South-Africa), 2022)Tuberculosis (TB) is a globally problematic infectious disease and is currently one of the leading causes of death from any infectious disease worldwide. Mycobacterium tuberculosis (MTB) is notorious for developing ... -
Elucidating the antimycobacterial mechanisms of ciprofloxacin and decoquinate derivative RMB041 on Mycobacterium tuberculosis using metabolomics
(North-West University (South Africa), 2022)Tuberculosis (TB) is amongst the leading causes of death brought about by a single infectious agent. Despite all the research done to date since the discovery of the infectious agent, Mycobacterium tuberculosis (Mtb) ... -
In vitro activity of artemisone and artemisinin derivatives against extracellular and intracellular Helicobacter pylori
(Elsevier, 2016)The in vitro activity of the new artemisinin derivative artemisone as well as other molecules of the same class against Helicobacter pylori and their effects when combined with standard antibiotics were evaluated. Since ... -
A model of isoniazid treatment of tuberculosis
(Elsevier, 2014)A mathematical model is presented of the growth and death of bacilli in a granuloma. The granuloma is treated with isoniazid (INH), a drug that inhibits the synthesis of mycolic acids (MA). Since MA is an essential component ... -
New insights into the survival mechanisms of rifampicin-resistant Mycobacterium tuberculosis
(Oxford Univ Press, 2016)Objectives: Rifampicin is considered the most important antibiotic for treating TB, but unfortunately Mycobacterium tuberculosis is rapidly developing resistance to this drug. Despite the fervent research efforts to date, ... -
Novel revelation of warfarin resistant mechanism in roof rats (Rattus rattus) using pharmacokinetic/pharmacodynamic analysis
(Elsevier, 2016)Roof rats (Rattus rattus) live mainly in human habitats. Heavy use of rodenticides, such as warfarin, has led to the development of drug resistance, making pest control difficult. There have been many reports regarding ... -
Potential anti-TB investigational compounds and drugs with repurposing potential in TB therapy: a conspectus
(Springer, 2020)The latest WHO report estimates about 1.6 million global deaths annually from TB, which is further exacerbated by drug-resistant (DR) TB and comorbidities with diabetes and HIV. Exiguous dosing, incomplete treatment course, ... -
Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues
(Elsevier, 2020)The emergence of drug-resistant tuberculosis (DR-TB) as well as the requirement for long, expensive and toxic drug regimens impede efforts to control and eliminate TB. Therefore, there’s a need for effective and affordable ...
