Browsing by Subject "Drug discovery"

Now showing items 1-4 of 4

    • Cell based assays for anti-Plasmodium activity evaluation 

      Mokgethi-Morule, Thabang; N'Da, David D. (Elsevier, 2016)
      Malaria remains one of the most common and deadly infectious diseases worldwide. The severity of this global public health challenge is reflected by the approximately 198 million people, who were reportedly infected in ...

    • The current development of CNS drug research 

      Wegener, Gregers; Rujescu, Dan (Oxford Univ Press, 2013)
      In the past few years, several high profiled pharmaceutical companies have decided to shut down major research activities within the central nervous system (CNS) area. For example, in December 2011 Novartis announced ...

    • Medicinal chemistry of polycyclic cage compounds in drug discovery research 

      Oliver, Douglas W.; Malan, Sarel F. (Springer, 2008)
      Saturated polycyclic hydrocarbon structures such as the monocyclic octane, bicylic norbornane and tricyclic adamantane have attracted the attention of several research groups since the 1930s. In the 1950s the synthesis of ...

    • Synthesis and antimycobacterial activity of disubstituted benzyltriazoles 

      Smit, Frans J.; Aucamp, Janine; N'Da, David D.; Seldon, Ronnett; Jordaan, Audrey (Springer, 2019)
      The increasing prevalence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb), the pathogen of human tuberculosis (TB), serves as a strong incentive for the discovery and development of new agents for the ...