Browsing by Subject "Detoxification"
Now showing items 1-10 of 10
-
Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase
(Elsevier, 2013)Human glycine N-acyltransferase (human GLYAT) detoxifies a wide range of endogenous and xenobiotic metabolites, including benzoate and salicylate. Significant inter-individual variation exists in glycine conjugation capacity. ... -
Characterization of the enzyme activity and substrate specificity of GLYAT haplotypes
(North-West University (South Africa), 2020)The unavoidable exposure to xenobiotics makes detoxification a necessity. Detoxification is not just one reaction but four reactions (Phase 0, I, II and III) that work together. The glycine conjugation pathway is one of ... -
Cloning and expression of human recombinant isoform a of glycine–N–acyltransferase
(North-West University, 2012)Awareness of detoxification, nowadays known as biotransformation, has become an integral part of our daily lives. It is a modern buzz word that is used to promote anything from health food to enhancement of performance in ... -
The establishment of a model system in which variants of the medium-chain ligase (ACSM) and glycine N-acyltransferase (GLYAT) can be co-expressed and analysed
(North-West University (South Africa), 2022)Even though glycine conjugation pathway discovery dates back to the 18th century, it is still an important detoxification pathway that is severely neglected in research. Xenobiotics are omnipresent in the environment (as ... -
The identification of genetic variation in the acyl-CoA synthetase genes (ACSM2A and ACSM2B)
(North-West University (South Africa), Potchefstroom Campus, 2016)Investigations into the role of the glycine conjugation pathway and specifically the functioning and significant importance of the mitochondrial medium-chain ligases have seriously been neglected over the last 30 years. ... -
Investigation and characterisation of the genetic variation in the coding region of the glycine N-acyltransferase gene
(North-West University, 2015)Thorough investigation of the glycine conjugation pathway has been neglected over the last 30 years. Environmental factors, nutrition, and the chronic use of medications are increasing the exposure of humans to benzoate ... -
Molecular methods for genotyping selected detoxification and DNA repair enzymes
(North-West University, 2010)The emerging field of personalized medicine and the prediction of side effects experienced due to pharmaceutical drugs is being studied intensively in the post genomic era. The molecular basis of inheritance and disease ... -
A new perspective on the importance of glycine N–acyltransferase in the detoxification of benzoic acid
(2014)Despite being the first biochemical reaction to be discovered, the glycine conjugation pathway remains poorly characterised. It has generally been assumed that glycine conjugation serves to increase the water solubility ... -
Sequencing and molecular characterization of variations in the glycine N–acyltransferase gene
(2014)Humans are continuously challenged by harmful endogenous and xenobiotic substances. Detoxification is the ability to neutralise and remove these substances from the body. Glycine N-acyltransferase, EC 2.3.1.13 (GLYAT) is ... -
Unbalanced biotransformation metabolism and oxidative stress status: implications for deficient fatty acid oxidation
(Scientific Research, 2011)The concept of accumulating xenobiotics within the human body as a health risk is well known. However, these compounds can also be endo-genous, as in the case of inborn errors of me-tabolism, and lead to some of the same ...
