Browsing by Subject "Deer mouse"
Now showing items 1-10 of 19
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Anxiety-like behaviour and adenosinergic processes in compulsive-like deer mice (Peromyscus maniculatus bairdii)
(North-West University (South-Africa), 2023)Obsessive-compulsive disorder (OCD)1 is characterized by recurring thoughts (obsessions) and rigid repetition of certain mental or behavioral actions (compulsions) that are often associated with anxiety. In terms of ... -
Cognitive flexibility in the deer mouse and its response to escitalopram and levetiracetam
(North-West University (South-Africa), 2022)Obsessive-compulsive disorder (OCD)1 causes functional impairment which severely and negatively impacts the lives of affected individuals. As its name suggests, OCD is characterised by both obsessions and compulsions. The ... -
Cognitive flexibility in the deer mouse model of obsessive-compulsive disorder and its response to serotonin and adenosine modulation
(North-West University (South-Africa), 2021)Obsessive-compulsive disorder (OCD)1 is a phenotypically heterogeneous psychiatric disorder characterised by repetitive and ritualised behaviours (compulsions), that are purportedly enacted to attenuate the level of distress ... -
Cortico-striatal cyclic AMP-phosphodiesterase-4 signalling and stereotypy in the deer mouse: attenuation after chronic fluoxetine treatment
(Elsevier, 2009)Motor stereotypies, described as repetitive, topographically invariant and seemingly purposeless behaviours, are common to several developmental and neuropsychiatric disorders. While drug induced stereotypy has been ... -
Cortico-striatal oxidative status, dopamine turnover and relation with stereotypy in the deer mouse
(Elsevier, 2011)The deer mouse presents with spontaneous stereotypic movements that resemble the repetitive behaviours of obsessive–compulsive disorder (OCD), and demonstrates a selective response to serotonin reuptake inhibitors. OCD has ... -
Ethological foundations of measuring obsessive-compulsive phenotypes in the deer mouse: a methodological perspective
(North-West University (South-Africa), 2020)Pre-clinical models which leverage the study of animal behavior are invaluable tools to advance our understanding of a variety of psychological constructs. Such ethological investigations allow us to gain insight into ... -
Excessive nest building is a unique behavioural phenotype in the deer mouse model of obsessive-compulsive disorder
(Sage, 2016)Obsessive–compulsive disorder (OCD) is a phenotypically heterogeneous condition characterised by time-consuming intrusive thoughts and/or compulsions. Irrespective of the symptom type diagnosed, the severity of OCD is ... -
An investigation into the potential neurobiological constructs and long-term biobehavioural effects of perinatal combined antiretroviral therapy (cART)-exposure in the deer mouse
(North-West University (South-Africa), 2022)South Africa has one of the largest combination antiretroviral treatment (cART1) programs in the world with an estimated 7.52 million individuals that were living with human immunodeficiency virus (HIV2) by the end of 2018. ... -
An investigation of habitual behaviour in deer mice (Peromyscus maniculatus bairdii) displaying motor persistence
(North-West University (South-Africa), 2023)Obsessive-compulsive disorder (OCD)1 is characterized by thematically specific obsessions, i.e. intrusive thoughts and impulses, and/or compulsions, that is highly repetitive behaviors or mental acts. Obsessions and ... -
A metagenomic microbiome investigation in the deer mouse : a translational approach to obsessive-compulsive disorder
(North-West University (South-Africa), 2019)Obsessive-compulsive disorder (OCD)1 is characterized by persistent, intrusive and often anxiety-provoking thoughts, i.e. obsessions and/or ritualistic behaviors (compulsions) that are expressed in an attempt to reduce the ...