Browsing by Subject "Coenzyme A"

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Glycine conjugation: importance in metabolism, the role of glycine N-acyltransferase, and factors that influence interindividual variation

Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Van Dijk, Alberdina Aike (Taylor & Francis, 2013)

Introduction: Glycine conjugation of mitochondrial acyl-CoAs, catalyzed by glycine N-acyltransferase (GLYAT, E.C. 2.3.1.13), is an important metabolic pathway responsible for maintaining adequate levels of free coenzyme A ...
A new perspective on the importance of glycine conjugation in the metabolism of aromatic acids

Badenhorst, Christoffel Petrus Stephanus; Erasmus, Elardus; Van der Sluis, Rencia; Nortje, Carla; Van Dijk, Alberdina Aike (Taylor & Francis, 2014)

A number of endogenous and xenobiotic organic acids are conjugated to glycine, in animals ranging from mosquitoes to humans. Glycine conjugation has generally been assumed to be a detoxification mechanism, increasing the ...
A new perspective on the importance of glycine N–acyltransferase in the detoxification of benzoic acid

Badenhorst, Christoffel Petrus Stephanus (2014)

Despite being the first biochemical reaction to be discovered, the glycine conjugation pathway remains poorly characterised. It has generally been assumed that glycine conjugation serves to increase the water solubility ...