Browsing by Subject "Circadian rhythm"

Now showing items 1-3 of 3

Behavioral, neuroendocrine and neurochemical studies on agomelatine in social isolation reared rats

Coutts, Dewald Eugene (North-West University (South Africa) , Potchefstroom Campus, 2015)

1. Introduction. There is currently a large body of evidence suggesting that stressful early life experiences, such as maternal separation and social isolation, may play a role in the development of major depressive disorder ...
Social isolation rearing-induced anxiety and response to agomelatine in male and female rats: role of corticosterone, oxytocin, and vasopressin

Harvey, Brian H.; Regenass, Wilmie; Dreyer, Walter; Möller, Marisa (Sage, 2019)

Background: The chronobiotic antidepressant, agomelatine, acts via re-entrainment of circadian rhythms. Earlier work has demonstrated late-life anxiety and reduced corticosterone in post-weaning social isolation reared ...
Studies into the anxiolytic actions of agomelatine in social isolation reared rats: role of corticosterone and sex

Regenass, Wilmie; Möller, Marisa; Harvey, Brian Herbert (Sage, 2018)

Anxiety disorders are severely disabling, while current pharmacological treatments are complicated by delayed onset, low remission rates and side-effects. Sex is also noted to contribute towards illness severity and treatment ...