Browsing by Subject "Aloe vera"
Now showing items 1-10 of 21
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Combining chemical permeation enhancers to obtain synergistic effects
(2014)The oral route of administration remains the preferred route of administrating drugs due to patient acceptance and compliance. Therapeutic proteins are currently mainly administered by means of the parenteral route because ... -
Combining selected medicinal plant extracts to improve wound healing of the skin
(North-West University (South-Africa), 2021)Throughout history plant-based medicines have been used for the treatment and management of wounds and some of these natural remedies are still very popular. Aloe vera gel is a well-known medicinal plant widely used in ... -
Development and evaluation of a double-phase multiple-unit dosage form for enhanced insulin intestinal delivery
(Bentham Science, 2018)Background: The oral route is the most preferred route of administration for selfmedication, but poor membrane permeability and pre-systemic degradation are key challenges that need to be addressed. Objective: The purpose ... -
Development of a mini-tablet-in-capsule dosage form for macromolecular drug delivery
(North-West University (South-Africa), 2020)Oral delivery of protein and peptide drugs faces immense challenges, partially due to the inherent unfavourable characteristics of the molecules and partially due to the unfavourable gastrointestinal environment. These ... -
Drug absorption enhancement capacities and mechanisms of action of Aloe vera gel materials
(North-West University (South Africa), Potchefstroom Campus, 2018)Oral drug delivery is one of the most preferred and user friendly routes of drug administration. Macromolecular drugs (such as peptides and proteins) generally have a poor bioavailability when administered orally. Absorption ... -
Effects of selected plant materials on in vitro wound healing using cell culture model
(North-West University (South-Africa), 2019)Since ancient times, wounds have been treated using plant based remedies. Of these remedies, Aloe species especially A. vera is probably the most prominent. Aloe vera is also the most studied of the Aloe genus in terms of ... -
Enhancing the solubility and in vitro permeability of pyrimethamine
(North-West University (South-Africa), 2021)ABSTRACT Malaria poses a substantial health problem, with nearly half of the world’s population susceptible to it. Malaria causes an estimated one million deaths per year. People who fall prey to malaria are also burdened ... -
Evaluation of isolated fractions of aloe vera gel materials on indinavir pharmacokinetics: in vitro and in vivo studies
(Bentham Science, 2016)Aloe vera is a plant with a long history of traditional medicinal use and is consumed in different products, sometimes in conjunction with prescribed medicines. A. vera gel has shown the ability to modulate drug absorption ... -
Gastrointestinal region specific insulin permeation enhancement by Aloe vera gel
(Bentham Science, 2020)Background: The oral administration route is still the most preferred by patients for drug treatment, but is unfortunately not suitable for all drug compounds. For example, protein and peptide drugs (e.g. insulin) are ... -
In vitro drug absorption enhancement effects of Aloe vera and Aloe ferox
(Österreichische Apotheker-Verlagsgesellschaft, 2012)The effect of whole leaf and gel materials from two aloe species (Aloe vera and A. ferox) was compared with that of the precipitated polysaccharides from these aloe materials on the transepithelial electrical resistance ...