Health Sciences
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Design, synthesis and evaluation of quinazolinone analogues as monoamine oxidase inhibitors
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, and it is estimated to affect approximately 1% of the population over the age of 65. PD is characterised by non-motor ... -
Occupational exposure of car guards to solar ultraviolet radiation in Potchefstroom
(North-West University (South Africa), Potchefstroom Campus, 2018)Introduction: Solar ultraviolet radiation (UVR) is an unavoidable physical workplace hazard to which outdoor workers such as car guards may be excessively exposed. A potential high risk of excessive exposure increases their ... -
Genetic and perinatal risk factors for movement disorders
(North-West University, Potchefstroom Campus., 2018)Movement disorders, such as Parkinson's disease (PD), Huntington's disease (HD) and cerebral palsy (CP) are debilitating diseases with a great societal impact. These disorders are characterized by damage to the basal ... -
Challenges with implementation of nutrition interventions aimed at non-communicable diseases among black urban South Africans
(North-West University (South Africa), Potchefstroom Campus, 2018)AIM - To investigate challenges to the implementation of nutrition interventions aimed at chronic non-communicable diseases (CNCDs) at government, community and individual levels in the Langa PURE study site in Cape Town, ... -
Effects of pre- and postnatal iron and n-3 fatty acid depletion, alone and in combination, on bone development in rats
(North-West University (South Africa), Potchefstroom Campus, 2018)A third of women and a fifth of men over the age of 50 worldwide are estimated to endure an osteoporotic fracture (Svedbom et al., 2013), and 75% of hip fractures are predicted to occur in developing countries by 2050 ... -
Validation of the Short Warwick-Edinburgh Mental Well-being Scale in a South African adult group
(North-West University (South Africa), Potchefstroom Campus, 2018)In the current exploration of the field of positive psychology, the construct of well-being and its different facets has increasingly become the focus of research. This has led to the development of various measuring ... -
Dietary intake of infants followed from age 6 to 18 months from a low socio-economic peri-urban community
(North-West University, Potchefstroom Campus, 2018)ABSTRACT Background During the complementary feeding period, children require foods with high nutrient density as they consume small amounts of food but have high growth and developmental needs (Dewey, 2013:2050) and to ... -
Mechanism of in vitro cytotoxicity of antimicrobial peptides in combination with stabilizing excipients
(North-West University, Potchefstroom Campus, 2018)Emerging antibiotic resistance poses a critical public health threat, particularly the alarming increase of resistant bacteria commonly associated with gastrointestinal (GI) infections. Antimicrobial peptides (AMPs) are a ... -
The synthesis and evaluation of benzosuberone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamine oxidase (MAO) is responsible for the catabolism of neurotransmitters such as serotonin and dopamine in the central nervous system and peripheral tissues. MAO inhibitors such as selegiline play a vital part in the ... -
Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin
(North-West University (South Africa), Potchefstroom Campus, 2018)The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ... -
The use of essential oils in relieving symptoms specific to brain malignancies : a systematic review
(North-West University (South Africa), Potchefstroom Campus, 2018)Background Brain-malignancy incidence is on the rise globally. Traditional treatment options for brain-malignancies such as surgery, radiation or chemotherapy bring about side-effects that may add to the already distressing ... -
Establishing three-dimensional cell culture models to measure biotransformation and toxicity
(North-West University, Potchefstroom Campus, 2018)A great proportion of new chemical entities will be terminated from the clinical drug development pipeline as a result of deficiencies in drug absorption, distribution, biotransformation and elimination as well as potential ... -
The psycho-hormonal influence of fatigue on amateur female soccer players
(North-West University (South Africa), Potchefstroom Campus, 2018)Soccer is rapidly becoming the most popular team sport played globally for both genders. However, literature describing the physical, physiological and psychological facets of female players is scarce. Various components ... -
Natural oil nano-emulsion dispersions for the topical delivery of clofazimine, artemisone and decoquinate
(North-West University, Potchefstroom Campus, 2018)Tuberculosis (TB), which is caused by Mycobacterium tuberculosis (Mtb) (Godreuil et al., 2007:1), manifests as an extra-pulmonary disease in 3.7 to 8.4% of cases, whereas cutaneous tuberculosis (CTB), which is uncommon, ... -
The synthesis and evaluation of tetralone derivatives as inhibitors of monoamine oxidase
(North-West University, Potchefstroom Campus, 2018)Monoamienoksidase (MAO)-inhibeerders word gebruik vir die behandeling van toestande wat veroorsaak word deur verlaagde vlakke van neuro-oordragstowwe soos dopamien, noradrenalien en serotonien. MAO-inhibeerders is aanvanklik ... -
Leukocyte telomere length and its relation to nitric oxide metabolites in a bi-ethnic sample: the SABPA study
(North-West University, Potchefstroom Campus, 2018)Aging of the cardiovascular system is associated with cardiovascular morbidity and mortality. One of the measures for biological aging is telomere length. Telomere length is considered to be more closely related to ... -
Untitled
(North-West University (South Africa), Potchefstroom Campus, 2018)Motivation It is well-known that both a high-salt diet and obesity are risk factors for the development of hypertension and cardiovascular disease. Several studies have suggested a link between dietary sodium and obesity. ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University (South Africa), Potchefstroom Campus, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
Exploring the role of identity configuration in decision-making towards behaviour change
(North-West University (South Africa), Potchefstroom Campus, 2018)Our personal identity is more than just our names and the roles we play on a day-to-day basis or our personalities but is rather more intricate. Defining our own identity is a lifelong process and becomes more complicated ... -
The synthesis and evaluation of dual inhibitors of monoamine oxidase and catechol-O-methyltransferase
(North-West University (South Africa), Potchefstroom Campus, 2018)Parkinson’s disease is the second most prevalent neurodegenerative disorder after Alzheimer’s disease. Parkinson’s disease is a debilitating, incurable, bradykinetic disorder which seriously inhibits a patient’s quality ...
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