Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates

Caira, Mino R.Stieger, NicoleLiebenberg, WilnaDe Villiers, Melgardt M.Samsodien, Halima2010-01-212010-01-212008Caira, M.R. et al. 2008. Solvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvates. Crystal growth & design, 8(1):17-23. [https://doi.org/10.1021/cg070522r]1528-7483 (Online)1528-7505http://hdl.handle.net/10394/2762https://pubs.acs.org/doi/abs/10.1021/cg070522rhttps://doi.org/10.1021/cg070522rFive crystalline solvates of the anti-HIV drug Nevirapine (N), with compositions N·(ethyl acetate)0.5 (1), N·(dichloromethane)0.5 (2), N·(toluene)0.5 (3), N·(water)0.5 (4), and N·(1,4-dioxane)1.5 (5), were isolated and examined by single-crystal X-ray diffraction to determine the topologies of guest inclusion. These features were reconciled with thermal decomposition data for the solvates recorded in thermogravimetric and differential scanning calorimetric tracesenSolvent inclusion by the anti-HIV drug nevirapine: X-ray structures and thermal decomposition of representative solvatesArticle