Brand, LindaWolmarans, De Wet2018-06-152018-06-152017Brand, L. & Wolmarans, D.W. 2017. Restoring the architecture: a rapid clinical perspective on bone-mineral density and osteoporosis. South African family practice, 59(6):22-31. [http://www.safpj.co.za/index.php/safpj/article/view/4774]2078-61902078-6204 (Online)http://hdl.handle.net/10394/27581http://www.safpj.co.za/index.php/safpj/article/view/4774/5690Osteoporosis is a highly prevalent and debilitating condition that contributes to the risk of fracture in both women and men. The current paper will provide a rapid clinical overview of the condition and the current pharmacotherapeutic approaches applied in its treatment. We close with a summary of novel treatment strategies currently being developed and explain the role of sequential combination therapy in the management of established osteoporosisenArticle