Möller, MarisaDu Preez, Jan L.Harvey, Brian HerbertEmsley, Robin2012-10-052012-10-052011Möller, M. et al. 2011. Isolation rearing-induced deficits in sensorimotor gating and social interaction in rats are related to cortico-striatal oxidative stress, and reversed by sub-chronic clozapine administration. European neuropsychopharmacology, 21(6):471-483. [https://doi.org/10.1016/j.euroneuro.2010.09.006]0924-977X1873-7862 (Online)http://hdl.handle.net/10394/7441https://www.sciencedirect.com/science/article/pii/S0924977X1000194Xhttps://doi.org/10.1016/j.euroneuro.2010.09.006The journal of the European College of NeuropsychopharmacologySocial isolation rearing (SIR) in rats induces behavioral and glutamatergic changes akin to schizophrenia. We studied the effects of 8 weeks SIR on cortico-striatal redox and social and cognitive behaviors in rats. SIR increased superoxide dismutase activity, decreased oxidized:reduced glutathione ratio and increased lipid peroxidation in both brain regions, and induced deficits in prepulse inhibition and social and self-directed interactive behaviors. Both behavioral and cortico-striatal redox disturbances were corrected by clozapine (5 mg/kg/day × 11 days). Behavioral changes evoked by SIR are associated with cortico-striatal oxidative stress that is reversed by clozapine treatment, providing novel insight into the neurobiology and treatment of schizophrenia.enSocial isolationPrepulse inhibitionSocial interactionClozapineSchizophreniaAnimal modelOxidative stressArticle