dc.contributor.author | Conradie, Karin Ronel | |
dc.contributor.author | Fourie, Catharina Maria Theresia | |
dc.contributor.author | Hoekstra, Tiny | |
dc.contributor.author | Pieters, Marlien | |
dc.contributor.author | Schutte, Aletta Elisabeth | |
dc.contributor.author | Van Rooyen, Johannes Marthinus | |
dc.date.accessioned | 2012-09-18T08:46:47Z | |
dc.date.available | 2012-09-18T08:46:47Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Fourie, C.M.T. et al. 2011. Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa?. Cardiovascular journal of Africa, 22(3):134-140. [http://www.cvja.co.za/information.php] | en_US |
dc.identifier.issn | 1995-1892 | |
dc.identifier.issn | 1996-3467 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/7393 | |
dc.identifier.uri | http://dx.doi.org/10.5830/CVJA-2010-056 | |
dc.description | CVJA is the official journal of the PASCAR (Pan African Society of Cardiology) | en_US |
dc.description.abstract | The chronic infection status suffered by HIV-infected individuals promotes chronic arterial inflammation and injury, which leads to dysfunction of the endothelium, atherosclerosis and thrombosis. Although HIV-1 subtype C is prevalent in South Africa and accounts for almost a third of the infections worldwide, this subtype differs genetically from HIV-1 subtype B on which the majority of studies have been done. The objective of this study was to assess whether newly identified, never-treated, HIV-1-infected South African participants showed signs of endothelial dysfunction, accelerated atherosclerosis and increased blood coagulation. We compared 300 newly diagnosed (never antiretroviral-treated) HIV-infected participants to 300 age-, gender-, body mass index- and locality-matched uninfected controls. Levels of high-density lipoprotein cholesterol (HDL-C), triglycerides, interleukin-6 (IL-6), C-reactive protein (CRP), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), fibrinogen and plasminogen activator inhibitor-1 (PAI-1), and carotid radialis pulse wave velocity (cr-PWV) were determined. The HIV-infected participants showed lower HDL-C and higher IL-6, CRP, ICAM-1 and VCAM-1 levels compared to the uninfected controls. No differences in fibrinogen and PAI-1 levels were detected. A continuous positive trend of increasing age with cr-PWV was detected in the HIV-infected group. Our findings suggest inflammatory injury of the endothelium, pointing to endothelial dysfunction of never-treated HIV-1-infected South Africans of African ancestry. Although no indication of a prothrombotic state could be detected, there was an indication of accelerated vascular aging and probable early atherosclerosis in the older HIV-infected participants. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Clinics Cardive | en_US |
dc.subject | HIV-1 | en_US |
dc.subject | endothelial dysfuncion | en_US |
dc.subject | vascular aging | en_US |
dc.subject | never treated | en_US |
dc.subject | inflammation | en_US |
dc.title | Is HIV-1 infection associated with endothelial dysfunction in a population of African ancestry in South Africa? | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 11294450 - Conradie, Karin Ronel | |
dc.contributor.researchID | 10062491 - Fourie, Catharina Maria Theresia | |
dc.contributor.researchID | 10059539 - Van Rooyen, Johannes Marthinus | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 10797920 - Pieters, Marlien | |