Synthesis, characterization and biological studies of some organotin-dithiocarbamate complexes
Adeyemi, Oluwasegun Jerry
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Organotin(IV)dithiocarbamate owe their functionality and usefulness to the individual attributes of the organotin and the dithiocarbamate moieties. The synergy exhibited by these moieties has resulted in the enhanced biological activity of the hybrid molecule. This thesis reports the synthesis, characterization and evaluation of the biological properties (including antimicrobial, antioxidant an~ anticancer activities) of series of organotin(IV) dithiocarbamate complexes. Organotin(IV) chlorides of various alky and aryl groups [RnSnCl4_n] (n = 1, 2; R = CH3, C4H9, C6Hs) were utilized, while the dithiocarbamate ligands [-S2CNRR'] (R= H, CH3, C2H5, C4H9, C3Hs and R'= C6Hs, C6Hs-CH2, CH3-C6Hs, C2Hs-C6Hs, C3Hs) were constituted of different alkyl, allyl and aryl substituents, resulting in array of compounds with different stereochemistry. All the complexes were characterized using spectroscopic techniques (FTIR, 1H and 13C and 119Sn NMR) and elemental analysis, and a few of them were further characterized by single crystal X-ray diffraction. The thermal decomposition properties of the complexes were studied using thermogravimetric analyser, and they displayed varying decomposition patterns to give tin sulfide residue of different phases. The antimicrobial properties of the complexes were studied using some gram positive bacteria (Bacillus cereus and Staphylococcus aureus), gram negative bacteria (Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa) and some fungi (Candida albicans and Aspergillus jlavus). They showed great potential as antimicrobial agents better than their respective ligands, and compared favorably with other standard drugs used as control. The complexes also exhibited potentials as antioxidant agents from the study carried out using 2,2-diphenyl-l-picrylhydrazyl (DPPH) and reducing power assays methods. Furthermore, the preliminary in vitro cytotoxicity activity study of the complexes was tested against tumor cell line human cervix carcinoma (HeLa). Activity ranged from very good to moderate, for all tested complexes. These complexes could be useful lead compounds m antibiotic, antioxidant and anticancer studies.