Fast and efficient nickel(II)-catalysed transfer hydrogenation of quinolines with ammonia borane
Date
2020Author
Vermaak, Vincent
Vosloo, Hermanus C.M.
Swarts, Andrew J.
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Herein we report the first Ni(II)‐catalysed transfer hydrogenation of quinolines using ammonia borane (AB) as hydrogen (H2) source. An in situ generated Ni(II)‐bis(pyrazolyl)pyridine pre‐catalyst could hydrogenate quinoline and its derivatives in excellent yields of up to 90% at 25 °C in 30 minutes. Spectroscopic studies revealed that a Ni(II)‐hydride is responsible for the transfer hydrogenation of quinoline to 1,2,3,4‐tetrahydroquinoline via a 1,4‐dihydroquinoline intermediate
URI
http://hdl.handle.net/10394/36391https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.202001147
https://doi.org/10.1002/adsc.202001147