dc.contributor.author | Mason, Shayne | |
dc.date.accessioned | 2020-06-04T07:37:08Z | |
dc.date.available | 2020-06-04T07:37:08Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mason, S. 2020. A novel, multi-faceted perception of lactate in neurology. Frontiers in neuroscience, 14: #460. [https://doi.org/10.3389/fnins.2020.00460] | en_US |
dc.identifier.issn | 1662-4548 | |
dc.identifier.issn | 1662-453X (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/34725 | |
dc.identifier.uri | https://www.frontiersin.org/articles/10.3389/fnins.2020.00460/pdf | |
dc.identifier.uri | https://doi.org/10.3389/fnins.2020.00460 | |
dc.description.abstract | Lactate has become one of the most re-evaluated metabolites in energy metabolism, particularly
as a shuttle in neuroenergetics (Mason, 2017; Ferguson et al., 2018). In a comprehensive review
in 2018, Brooks, one of the originators of the “lactate shuttle” concept, discusses the roles that
lactate plays in the delivery of oxidative, and gluconeogenic substrates, as well as in cell signaling
(Brooks, 2018). Brooks also appraises clinical studies that feature lactate to treat pro-inflammatory
conditions, as well as reports on historic and recent studies of lactate metabolism and shuttling.
A pioneering astrocyte–neuron lactate shuttle (ANLS) hypothesis was first proposed in 1994 by
Pellerin and Magistretti for homeostatic conditions within the brain (Pellerin and Magistretti,
1994). The ANLS hypothesis has withstood challenges for 25 years but remains controversial
as scientists continue to debate its validity (Bak and Walls, 2018; Barros and Weber, 2018). I
believe, however, that the ANLS hypothesis can be extended beyond homeostatic conditions into
neuropathophysiological states. The focus of this short opinion paper is to highlight studies over
the past 2 years that support the notion that the route of lactate, as it acts as a shuttle in the
brain, in neuropathophysiological states is emerging as crucial in neuroenergetics. This behavior is
reviewed in more detail by Mason (2017). Further, this paper presents recent experimental evidence
that has emerged supporting an extension of the ANLS—the newly postulated astrocyte–microglia
lactate shuttle (AMLS) hypothesis (Mason et al., 2015), as described for the infectious, chronic
neuroinflammatory disease tuberculous meningitis (TBM) | en_US |
dc.language.iso | en | en_US |
dc.publisher | Frontiers Media | en_US |
dc.subject | Lactate | en_US |
dc.subject | Neurology | en_US |
dc.subject | Traumatic brain injury (TBI) | en_US |
dc.subject | Neurodegenerative disease | en_US |
dc.subject | Tuberculous meningitis (TBM) | en_US |
dc.title | A novel, multi-faceted perception of lactate in neurology | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 21487855 - Mason, Shayne William | |