dc.contributor.author | De Abreu, Murilo S. | |
dc.contributor.author | Harvey, Brian H. | |
dc.contributor.author | Vlok, Marli | |
dc.contributor.author | Giacomini, Ana C.V.V. | |
dc.contributor.author | Genario, Rafael | |
dc.date.accessioned | 2020-05-08T11:27:22Z | |
dc.date.available | 2020-05-08T11:27:22Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | De Abreu, M.S. et al. 2020. Non-pharmacological and pharmacological approaches for psychiatric disorders: re-appraisal and insights from zebrafish models. Pharmacology, biochemistry and behavior, 193: #172928. [https://doi.org/10.1016/j.pbb.2020.172928] | en_US |
dc.identifier.issn | 0091-3057 | |
dc.identifier.uri | http://hdl.handle.net/10394/34604 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0091305720301167#! | |
dc.identifier.uri | https://doi.org/10.1016/j.pbb.2020.172928 | |
dc.description.abstract | Acute and chronic stressors are common triggers of human mental illnesses. Experimental animal models and their cross-species translation to humans are critical for understanding of the pathogenesis of stress-related psychiatric disorders. Mounting evidence suggests that both pharmacological and non-pharmacological approaches can be efficient in treating these disorders. Here, we analyze human, rodent and zebrafish (Danio rerio) data to compare the impact of non-pharmacological and pharmacological therapies of stress-related psychopathologies. Emphasizing the likely synergism and interplay between pharmacological and environmental factors in mitigating daily stress both clinically and in experimental models, we argue that environmental enrichment emerges as a promising complementary therapy for stress-induced disorders across taxa. We also call for a broader use of novel model organisms, such as zebrafish, to study such treatments and their potential interplay | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Psychopharmacotherapy | en_US |
dc.subject | Acute and chronic stress | en_US |
dc.subject | Animal model | en_US |
dc.subject | Mental illness | en_US |
dc.subject | Environmental enrichment | en_US |
dc.title | Non-pharmacological and pharmacological approaches for psychiatric disorders: re-appraisal and insights from zebrafish models | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 11083417 - Harvey, Brian Herbert | |
dc.contributor.researchID | 13014196 - Vlok, Martha Carolina | |