Show simple item record

dc.contributor.advisorKruger, H.S.
dc.contributor.advisorUkegbu, P.O.
dc.contributor.authorVan der Merwe, Carlien
dc.date.accessioned2019-12-03T06:34:17Z
dc.date.available2019-12-03T06:34:17Z
dc.date.issued2019
dc.identifier.urihttps://orcid.org/0000-0003-0364-1113
dc.identifier.urihttp://hdl.handle.net/10394/33796
dc.descriptionMSc (Dietetics), North-West University, Potchefstroom Campusen_US
dc.description.abstractBackground: Osteoporosis affects millions of people, especially postmenopausal women, worldwide. Osteoporosis and associated fractures are also becomming a concern in the HIV-positive population as a result of higher life expectancy and possible fragility fractures due to the advancement in antiretroviral therapy (ART); increased prevalence of low bone mineral density (BMD) as a result of ART-induced bone demineralization as well as increased bone loss due the HIV-infection it self. Urbanisation also places the urban HIV-positive postmenopausal women at risk for the development of low BMD. In South Africa rapid urbanisation is associated with dietary and lifestyle changes that negatively influence BMD. Thus, the effects of long term use of ART in combination with other factors associated with the aging body as well as urbanisation are a concern. Objectives: This study aimed to determine the number of fracture risk factors and the association with BMD in black postmenopausal HIV-positive women on highly active antiretroviral therapy (HAART). Methods: This study was a cross-sectional analysis and baseline data from 120 HIV-positive black post-menopausal women in a prospective cohort study in the North West Province of South Africa was used. Bone mineral density (at the spine, left femoral neck and total body) was measured by dual X-ray absorptiometry (DXA). The number of fracture risk was determined using a checklist. Multivariate linear regression models were applied to assess associations of fracture risk score with site specific BMDs, adjusting for age, calcium intake, serum vitamin D, duration of HIV infection, duration of HAART and physical activity. Results: All participants had the age (>40 years) and female sex risk factors, with 39.2% having only two and 37.5% having three risk factors. The maximum number of risk factors was five. Age and underweight were the only individual risk factors significantly associated with BMD. In adjusted models, only age was significantly associated with BMD, but fracture risk was included in the final model for spine BMD and left femoral neck BMD. No significant association between fracture risk score and BMD was found. Conclusions: A maximum of five fracture risk factors were found, but fracture risk score was not significantly associated with BMD in this group of HIV-positive women.en_US
dc.language.isoenen_US
dc.publisherNorth-West University (South-Africa)en_US
dc.subjectHIVen_US
dc.subjectPostmenopausalen_US
dc.subjectBMDen_US
dc.subjectOsteoporosisen_US
dc.subjectFracture risken_US
dc.subjectAfricaen_US
dc.titleThe association between fracture risk and bone mineral density in black postmenopausal HIV-positive women on HAARTen_US
dc.typeThesisen_US
dc.description.thesistypeMastersen_US
dc.contributor.researchID10061568 - Kruger, Herculina Salome (Supervisor)||30249864 - Ukegbu, Patricia Ogechi (Supervisor)


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record