Show simple item record

dc.contributor.authorIchikawa, Go
dc.contributor.authorIkenaka, Yoshinori
dc.contributor.authorKuribayashi, Ryota
dc.contributor.authorIchise, Takahiro
dc.contributor.authorNakayama, Shouta M.M.
dc.date.accessioned2019-08-12T13:44:35Z
dc.date.available2019-08-12T13:44:35Z
dc.date.issued2019
dc.identifier.citationIchikawa, G. et al. 2019. LC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birth. PLoS ONE, 14(7): Article no e0219208. [https://doi.org/10.1371/journal.pone.0219208]en_US
dc.identifier.issn1932-6203 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/33211
dc.identifier.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0219208&type=printable
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0219208
dc.description.abstractObjectives Neonicotinoid insecticides are widely used systemic pesticides with nicotinic acetylcholine receptor agonist activity that are a concern as environmental pollutants. Neonicotinoids in humans and the environment have been widely reported, but few studies have examined their presence in fetuses and newborns. The objective of this study is to determine exposure to neonicotinoids and metabolites in very low birth weight (VLBW) infants. Methods An analytical method for seven neonicotinoids and one neonicotinoid metabolite, N-desmethylacetamiprid (DMAP), in human urine using LC-ESI/MS/MS was developed. This method was used for analysis of 57 urine samples collected within 48 hours after birth from VLBW infants of gestational age 23–34 weeks (male/female = 36/21, small for gestational age (SGA)/appropriate gestational age (AGA) = 6/51) who were admitted to the neonatal intensive care unit of Dokkyo Hospital from January 2009 to December 2010. Sixty-five samples collected on postnatal day 14 (M/F = 37/22, SGA/AGA = 7/52) were also analyzed. Results DMAP, a metabolite of acetamiprid, was detected in 14 urine samples collected at birth (24.6%, median level 0.048 ppb) and in 7 samples collected on postnatal day 14 (11.9%, median level 0.09 ppb). The urinary DMAP detection rate and level were higher in SGA than in AGA infants (both p<0.05). There were no correlations between the DMAP level and infant physique indexes (length, height, and head circumference SD scores). Conclusion These results provide the first evidence worldwide of neonicotinoid exposure in newborn babies in the early phase after birth. The findings suggest a need to examine potential neurodevelopmental toxicity of neonicotinoids and metabolites in human fetusesen_US
dc.language.isoenen_US
dc.publisherPLoSen_US
dc.titleLC-ESI/MS/MS analysis of neonicotinoids in urine of very low birth weight infants at birthen_US
dc.typeArticleen_US
dc.contributor.researchID27878368 - Ikenaka, Yoshinori


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record