dc.contributor.author | Mandiwana, Vusani | |
dc.contributor.author | Grobler, Anne | |
dc.contributor.author | Zeevaart, Jan Rijn | |
dc.contributor.author | Kalombo, Lonji | |
dc.date.accessioned | 2018-09-26T06:43:20Z | |
dc.date.available | 2018-09-26T06:43:20Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Mandiwana, V. et al. 2018. 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles. Applied radiation and isotopes, 141:51-56. [https://doi.org/10.1016/j.apradiso.2018.08.015] | en_US |
dc.identifier.issn | 0969-8043 | |
dc.identifier.issn | 1872-9800 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/31111 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0969804317307005 | |
dc.identifier.uri | https://doi.org/10.1016/j.apradiso.2018.08.015 | |
dc.description.abstract | The aim of this study was to establish the in vivo uptake and tissue distribution of 99mTc-MDP-encapsulated Solid Lipid Nanoparticles (SLNs) post administration. Radioactive 99mTc-MDP encapsulated into SLNs was administered to rats to trace their biodistribution through imaging and ex vivo studies. As expected IV injected 99mTc-MDP exhibited predominant visual bone uptake and a high localisation of particles in the kidneys (3.87%ID/g) followed by bone (2.66%ID/g). IV administered 99mTc-MDP encapsulated by SLN showed similar uptake than 99mTc-MDP. Orally administrated 99mTc-MDP showed no uptake in any organs except the GI-tract while orally administered 99mTc-MDP-SLN showed distinct transfer of 99mTc-MDP from the GI tract with measurable levels in the kidneys and bone | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Biodistribution | en_US |
dc.subject | In vivo imaging | en_US |
dc.subject | SLNs | en_US |
dc.subject | 99mTc-MDP | en_US |
dc.title | 99mTc-MDP as an imaging tool to evaluate the in vivo biodistribution of solid lipid nanoparticles | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 24045756 - Mandiwana, Vusani | |
dc.contributor.researchID | 11008857 - Grobler, Anne Frederica | |
dc.contributor.researchID | 16951484 - Zeevaart, Jan Rijn | |