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dc.contributor.authorEkoru, K.
dc.contributor.authorFourie, C.M.
dc.contributor.authorKruger, I.M.
dc.contributor.authorSchutte, A.E.
dc.contributor.authorVorster, E.H.
dc.date.accessioned2018-08-21T12:52:18Z
dc.date.available2018-08-21T12:52:18Z
dc.date.issued2018
dc.identifier.citationEkoru, K. et al. 2018. HIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africa. Global health epidemiology and genomics, 3: Article no e7. [https://doi.org/10.1017/gheg.2018.7]en_US
dc.identifier.issn2054-4200
dc.identifier.urihttp://hdl.handle.net/10394/30757
dc.identifier.urihttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/E7C32E1B38451A8F77D05A7F6440A338/S2054420018000076a.pdf/hiv_treatment_is_associated_with_a_twofold_higher_probability_of_raised_triglycerides_pooled_analyses_in_21_023_individuals_in_subsaharan_africa.pdf
dc.identifier.urihttps://doi.org/10.1017/gheg.2018.7
dc.description.abstractBackground Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there are limited data on the impact of ART on cardiometabolic risk in sub- Saharan African (SSA) populations. Methods Pooled analyses of 14 studies comprising 21 023 individuals, on whom relevant cardiometabolic risk factors (including TG), HIV and ART status were assessed between 2003 and 2014, in SSA. The association between ART and raised TG (>2.3 mmol/L) was analysed using regression models. Findings Among 10 615 individuals, ART was associated with a two-fold higher probability of raised TG (RR 2.05, 95% CI 1.51–2.77, I2 = 45.2%). The associations between ART and raised blood pressure, glucose, HbA1c, and other lipids were inconsistent across studies. Interpretation Evidence from this study confirms the association of ART with raised TG in SSA populations. Given the possible causal effect of raised TG on cardiovascular disease (CVD), the evidence highlights the need for prospective studies to clarify the impact of long term ART on CVD outcomes in SSAen_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectHIVen_US
dc.subjectLipidsen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectTriglyceridesen_US
dc.titleHIV treatment is associated with a twofold higher probability of raised triglycerides: pooled analyses in 21 023 individuals in sub-Saharan Africaen_US
dc.typeArticleen_US
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12079642 - Kruger, Iolanthé Marike
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia


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