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dc.contributor.authorHavenga, Kaylee
dc.contributor.authorSteyn, Dewald
dc.contributor.authorHamman, Josias
dc.contributor.authorAbay, Efrem
dc.contributor.authorWiesner, Lubbe
dc.contributor.authorViljoen, Alvaro
dc.date.accessioned2018-08-17T14:08:03Z
dc.date.available2018-08-17T14:08:03Z
dc.date.issued2018
dc.identifier.citationHavenga, K. et al. 2018. The in vitro and in vivo effects of hypoxis hemerocallidea on indinavir pharmacokinetics: modulation of efflux. Planta medica, 84(12-13):895-901. [https://doi.org/10.1055/a-0607-2743]en_US
dc.identifier.issn0032-0943
dc.identifier.issn1439-0221 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/30724
dc.identifier.urihttps://doi.org/10.1055/a-0607-2743
dc.description.abstract(African potato) is a popular medicinal plant that has been used traditionally for the treatment of various disorders. Some HIV/AIDS patients use this traditional medicine together with their antiretroviral therapy. This study aimed to determine the impact of selected materials (i.e., a commercial product, an aqueous extract, and biomass reference plant material) on the bidirectional permeability of indinavir across Caco-2 cell monolayers as well as the bioavailability of indinavir during an acute, single administration study in Sprague-Dawley rats. All of the selected test materials demonstrated inhibition effects on indinavir efflux across Caco-2 cell monolayers, albeit to different extents. An increase in the bioavailability of indinavir was obtained when administered concomitantly with the materials, albeit not statistically significantly. The change in bioavailability directly correlated with the permeability results. It can therefore be concluded that the change in permeability and bioavailability of indinavir was caused by efflux inhibition and this effect was dependent on the type of material investigated, which was found to be in the following order: commercial product > aqueous extract > reference plant material. The clinical significance of the combined effect of efflux and metabolism inhibition by should be determined in another model that expresses the cytochrome P450 3A4 enzymeen_US
dc.language.isoenen_US
dc.publisherThiemeen_US
dc.titleThe in vitro and in vivo effects of hypoxis hemerocallidea on indinavir pharmacokinetics: modulation of effluxen_US
dc.typeArticleen_US
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID12297305 - Steyn, Johan Dewald


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