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dc.contributor.authorStrauss, Michél
dc.contributor.authorSmith, Wayne
dc.contributor.authorKruger, Ruan
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorWei, Wen
dc.date.accessioned2018-08-07T12:58:41Z
dc.date.available2018-08-07T12:58:41Z
dc.date.issued2018
dc.identifier.citationStrauss, M. et al. 2018. Marinobufagenin and left ventricular mass in young adults: the African-PREDICT study. European journal of preventive cardiology, 25(15):1587-1595. [https://doi.org/10.1177/2047487318788140]en_US
dc.identifier.issn2047-4873
dc.identifier.issn2047-4881 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/30654
dc.identifier.urihttps://doi.org/10.1177/2047487318788140
dc.identifier.urihttp://journals.sagepub.com/doi/full/10.1177/2047487318788140
dc.description.abstractBackground The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that elevated marinobufagenin adversely associates with cardiac and renal, structural and functional alterations. It remains uncertain whether marinobufagenin relates to the early stages of target organ damage development, especially in young adults without cardiovascular disease. We therefore explored whether elevated 24-hour urinary marinobufagenin excretion was related to indices of subclinical target organ damage in young healthy adults. Design This cross-sectional study included 711 participants from the African-PREDICT study (black 51%, men 42%, 24.8 ± 3.02 years). Methods We assessed cardiac geometry and function by two-dimensional echocardiography and pulse wave Doppler imaging. 24-Hour urinary marinobufagenin and sodium excretion were measured, and the estimated glomerular filtration rate determined. Results Across marinobufagenin excretion quartiles, left ventricular mass (P < 0.001), end diastolic volume (P < 0.001), stroke volume (P = 0.004) and sodium excretion (P < 0.001) were higher within the fourth compared with the first quartile. Partial regression analyses indicated that left ventricular mass (r = 0.08, P = 0.043), end diastolic volume (r = 0.10, P = 0.010) and stroke volume (r = 0.09, P = 0.022) were positively related to marinobufagenin excretion. In multivariate-adjusted regression analysis, left ventricular mass associated positively with marinobufagenin excretion only in the highest marinobufagenin excretion quartile (adjusted R2 = 0.20; β = 0.15; P = 0.043). This relationship between left ventricular mass and marinobufagenin excretion was evident in women (adjusted R2 = 0.06; β = 0.127; P = 0.015) but not in men (adjusted R2 = 0.06; β = 0.007; P = 0.92). Conclusions Left ventricular mass positively and independently associates with marinobufagenin excretion in young healthy adults with excessively high marinobufagenin excretion. Women may be more sensitive to the effects of marinobufagenin on early structural cardiac changesen_US
dc.language.isoenen_US
dc.publisherSageen_US
dc.subjectApparently healthyen_US
dc.subjectLeft ventricular mass indexen_US
dc.subjectMarinobufageninen_US
dc.subjectYoung adultsen_US
dc.titleMarinobufagenin and left ventricular mass in young adults: the African-PREDICT studyen_US
dc.typeArticleen_US
dc.contributor.researchID23423714 - Strauss, Michél
dc.contributor.researchID20035632 - Kruger, Ruan
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID22945717 - Smith, Wayne


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